Department of Oral and Maxillofacial Surgery Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Department of Emergency and Critical Care Medicine Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Intensive Crit Care Nurs. 2023 Aug;77:103433. doi: 10.1016/j.iccn.2023.103433. Epub 2023 Mar 27.
To evaluate the prevalence of oral complications in patients with severe COVID-19; investigate the association between their oral health, organ status, and immunity; and determine whether the resazurin disc test is an effective substitute for the Oral Assessment Guide.
RESEARCH METHODOLOGY/DESIGN: A single-centre observational study.
Intensive care unit with restricted access specialising in extracorporeal membrane oxygenation for COVID-19 treatment.
We investigated the oral health of 13 patients with COVID-19 receiving extracorporeal membrane oxygenation therapy between April and December 2021 using the Oral Assessment Guide and colour reactive resazurin disc test. The Sequential Organ Failure Assessment and Prognostic Nutritional Index were used to assess organ status and immunity, respectively. The correlation of oral health status with organ status and immunity was investigated.
High bacterial levels, revealed by the resazurin disc test, were associated with elevated Oral Assessment Guide scores, indicating oral health deterioration, particularly in terms of teeth and dentures. Increased Sequential Organ Failure Assessment scores and decreased Prognostic Nutritional Index were correlated with poor oral health, revealed by the Oral Assessment Guide and resazurin disc test.
Poor oral health is an important risk factor for severe COVID-19 complications in patients admitted to an intensive care unit. The Oral Assessment Guide and resazurin disc test can evaluate oral conditions; however, the resazurin disc test is quantitative and does not require salivary specimens to be transferred outside the patient ward for evaluation. The resazurin disc test can be a useful substitute for the Oral Assessment Guide in intensive care units with restricted access.
The resazurin disc test can be used for quantitative assessment of patients' oral condition in isolation wards. Multidisciplinary management of patients with COVID-19 should be promoted and involve oral healthcare providers such as dentists and dental hygienists.
评估重症 COVID-19 患者的口腔并发症患病率；调查其口腔健康、器官状况和免疫之间的关系；并确定 Resazurin 圆盘试验是否是口腔评估指南的有效替代方法。
研究方法/设计：一项单中心观察性研究。
限制进入的重症监护室，专门从事 COVID-19 治疗的体外膜肺氧合。
我们使用口腔评估指南和颜色反应 Resazurin 圆盘试验调查了 2021 年 4 月至 12 月期间接受体外膜肺氧合治疗的 13 例 COVID-19 患者的口腔健康状况。使用序贯器官衰竭评估和预后营养指数分别评估器官状况和免疫。调查了口腔健康状况与器官状况和免疫的相关性。
Resazurin 圆盘试验显示的高细菌水平与口腔评估指南评分升高相关，表明口腔健康恶化，尤其是牙齿和义齿方面。升高的序贯器官衰竭评估评分和降低的预后营养指数与口腔评估指南和 Resazurin 圆盘试验显示的口腔健康不良相关。
重症 COVID-19 患者入住重症监护室时，口腔健康不良是严重并发症的重要危险因素。口腔评估指南和 Resazurin 圆盘试验可评估口腔状况；然而，Resazurin 圆盘试验是定量的，不需要将唾液标本转移到患者病房外进行评估。Resazurin 圆盘试验可以成为限制进入的重症监护室中口腔评估指南的有用替代方法。
Resazurin 圆盘试验可用于隔离病房中患者口腔状况的定量评估。应提倡多学科管理 COVID-19 患者，并包括口腔保健提供者，如牙医和口腔卫生师。
