Yiannikas J, Takatani S, MacIntyre W J, Underwood D A, Cook S A, Go R T, Golding L, Nose Y, Loop F D
Eur J Nucl Med. 1986;11(10):375-80. doi: 10.1007/BF00261400.
Using pusher-plate-type artificial hearts, changes in the degree of synchrony and stroke volume were compared to phase and amplitude calculations from the first Fourier component of individual-pixel time-activity curves generated from gated radionuclide images (RNA) of these hearts. In addition, the ability of Fourier analysis to quantify paradoxical volume shifts was tested using a ventricular aneurysm model by which the Fourier amplitude was correlated to known increments of paradoxical volume. Predetermined phase-angle differences (incremental increases in asynchrony) and the mean phase-angle difference calculated from RNAs showed an agreement of -7 degrees +/- 4.4 degrees (mean +/- SD). A strong correlation was noted between stroke volume and Fourier amplitude (r = 0.98; P less than 0.0001) as well as between the paradoxical volume accepted by the 'aneurysm' and the Fourier amplitude (r = 0.97; P less than 0.0001). The degree of asynchrony and changes in stroke volume were accurately reflected by the Fourier phase and amplitude values, respectively. In the specific case of ventricular aneurysms, the data demonstrate that using this method, the paradoxically moving areas may be localized, and the expansile volume within these regions can be quantified.
使用推板型人工心脏，将同步程度和每搏输出量的变化与从这些心脏的门控放射性核素图像（RNA）生成的单个像素时间-活性曲线的第一傅里叶分量的相位和幅度计算结果进行比较。此外，使用心室瘤模型测试了傅里叶分析量化矛盾性容量变化的能力，通过该模型将傅里叶幅度与已知的矛盾性容量增量相关联。预定的相位角差异（异步性的增量增加）以及从RNA计算出的平均相位角差异显示一致性为-7度±4.4度（平均值±标准差）。每搏输出量与傅里叶幅度之间（r = 0.98；P < 0.0001）以及“动脉瘤”接受的矛盾性容量与傅里叶幅度之间（r = 0.97；P < 0.0001）均存在强相关性。傅里叶相位和幅度值分别准确反映了异步程度和每搏输出量的变化。在心室瘤的特定情况下，数据表明使用该方法可以定位矛盾性移动区域，并可以量化这些区域内的扩张容量。
