Wendt R E, Murphy P H, Clark J W, Burdine J A
J Nucl Med. 1982 Aug;23(8):715-24.
First-harmonic Fourier analysis is currently used to aid in the interpretation of multigated cardiac studies. Its intrinsic inaccuracies are not generally appreciated. This study investigates the characteristics and magnitudes of the errors of this technique. The study analyzes computer-generated phantoms that isolate the various motions of the ventricles (contraction, translation, and rotation) with the first-harmonic approach. The first-harmonic output is compared with a more accurate fitting scheme using multiple terms of the Fourier expansion. Significant artifacts of the inaccuracy of the first harmonic appear in the phantom studies and are observed in patient examples. We conclude that caution is needed in interpreting first-harmonic phase and amplitude images, and particularly in associating them with parameters like the onset of contraction and the stroke volume.
一次谐波傅里叶分析目前用于辅助解读多门控心脏研究。其固有的不准确性通常未得到充分认识。本研究调查了该技术误差的特征和大小。该研究使用一次谐波方法分析了计算机生成的模拟模型，这些模型分离了心室的各种运动（收缩、平移和旋转）。将一次谐波输出与使用傅里叶展开多项的更精确拟合方案进行比较。在模拟模型研究中出现了一次谐波不准确的显著伪影，并在患者实例中观察到。我们得出结论，在解释一次谐波相位和幅度图像时需要谨慎，尤其是在将它们与诸如收缩起始和每搏输出量等参数相关联时。
