Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.
Trends Mol Med. 2023 Jun;29(6):422-424. doi: 10.1016/j.molmed.2023.03.003. Epub 2023 Mar 27.
Deng and colleagues highlight the importance of understanding the divergent roles of β2-adrenoceptor (βAR) in high-fat diet-induced heart failure. βAR signaling has beneficial and detrimental effects depending on the context and level of activation. We discuss the importance of these findings and their implications in developing effective and safe therapies.
邓及其同事强调了理解β2-肾上腺素能受体（βAR）在高脂肪饮食诱导的心力衰竭中的不同作用的重要性。βAR 信号根据上下文和激活水平具有有益和有害的影响。我们讨论了这些发现的重要性及其在开发有效和安全治疗方法中的意义。
