Twery M J, Kirkpatrick B, Critcher E C, Lewis M H, Mailman R B, Cooper C W
Eur J Pharmacol. 1986 Feb 18;121(2):189-98. doi: 10.1016/0014-2999(86)90490-5.
In rats treated with salmon calcitonin (CT) administered intracerebroventricularly (i.c.v., 85 or 8.5 pmol), spasmodic body movements, hopping and tail jerks, collectively termed dyskinesia, appeared within 1 h of administration and persisted for at least 24 h. In addition, spontaneous grooming, rearing and locomotion occurred less often in CT-treated rats than in vehicle-injected animals, while the incidence of both sniffing and nose poking remained essentially unchanged. The CT failed to displace either [3H]dopamine or [3H]spiperone from striatal membranes, and the behavioral effects were not blocked by haloperidol or SCH 23390, suggesting that the peptide did not directly affect dopamine receptors. The dyskinesia was not blocked by scopolamine, atropine, muscimol, diazepam or ketanserin. These data are consistent with the hypothesis that a compound with recognition characteristics similar to those of salmon CT may function as a neurotransmitter-modulator in the central nervous system.
在经脑室内注射鲑鱼降钙素（CT，85或8.5皮摩尔）处理的大鼠中，给药后1小时内出现痉挛性身体运动、跳跃和甩尾，统称为运动障碍，并持续至少24小时。此外，与注射赋形剂的动物相比，经CT处理的大鼠自发梳理毛发、直立和移动的频率更低，而嗅探和探鼻的发生率基本保持不变。CT未能从纹状体膜上取代[3H]多巴胺或[3H]螺哌隆，且行为效应未被氟哌啶醇或SCH 23390阻断，这表明该肽并未直接影响多巴胺受体。运动障碍未被东莨菪碱、阿托品、蝇蕈醇、地西泮或酮色林阻断。这些数据与以下假设一致：一种具有与鲑鱼CT相似识别特征的化合物可能在中枢神经系统中作为神经递质调节剂发挥作用。
