Twery M J, Kirkpatrick B, Lewis M H, Mailman R B, Cooper C W
Pharmacol Biochem Behav. 1986 May;24(5):1203-7. doi: 10.1016/0091-3057(86)90171-1.
Using an automated testing apparatus, the hypermotility induced by amphetamine had previously been found to be inhibited by intracerebroventricular (ICV) administration of salmon calcitonin (CT). The present study used a computer-supported direct observational method to characterize further the interactions of CT and amphetamine. After treatment with amphetamine (1.5 mg/kg, IP), the incidence of rearing, nose poking, and locomotion was reduced in rats that were pretreated with 85 pmol salmon CT ICV; the incidence of sniffing and grooming remained unchanged. CT-induced dyskinesia, a unique consequence of central CT treatment, was attenuated but not abolished by administration of amphetamine. These results support the premise that a compound with receptor recognition characteristics similar to those of salmon CT may act as a neurotransmitter-modulator in the central nervous system.
使用自动测试装置，先前已发现安非他明诱导的运动亢进可被脑室内（ICV）注射鲑鱼降钙素（CT）所抑制。本研究采用计算机辅助直接观察法进一步表征CT与安非他明的相互作用。在用安非他明（1.5毫克/千克，腹腔注射）处理后，预先经ICV注射85皮摩尔鲑鱼CT的大鼠中，竖毛、探鼻和运动的发生率降低；嗅闻和梳理的发生率保持不变。CT诱导的运动障碍是中枢CT治疗的独特后果，给予安非他明可使其减轻但未消除。这些结果支持这样一个前提，即具有与鲑鱼CT相似受体识别特征的化合物可能在中枢神经系统中充当神经递质调节剂。
