创伤后应激症状严重程度可预测退伍军人认知能力下降，超出阿尔茨海默病生物标志物的影响。
Posttraumatic stress symptom severity predicts cognitive decline beyond the effect of Alzheimer's disease biomarkers in Veterans.
机构信息
Department of Psychology, The Ohio State University, Columbus, OH, USA.
Chronic Brain Injury Initiative, The Ohio State University, Columbus, OH, USA.
出版信息
Transl Psychiatry. 2023 Mar 29;13(1):102. doi: 10.1038/s41398-023-02354-0.
Chronic stress is a risk factor for dementia but whether it explains unique variance in cognitive decline in older adults above Alzheimer's disease (AD) biomarkers is unknown. In a preclinical cohort of Vietnam Veterans, we examined the relationship between posttraumatic stress disorder (PTSD) symptom severity, AD biomarkers of beta-amyloid (Aβ) and tau, and change in cognitive performance on two widely-used screeners, the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Analyses indicated that PTSD symptom severity was associated with a greater decline on the MMSE (p < 0.04) and MoCA (p < 0.024) after adjusting for biomarkers of AD, notably on the attention scale of the MoCA and the memory index of the MMSE. These analyses survived multiple comparison corrections. Taken together, PTSD symptom severity is associated with accelerated cognitive decline. Treating PTSD should be considered instrumental to maintaining cognitive function as adults age.
慢性应激是痴呆的一个风险因素，但它是否能解释老年人群中除阿尔茨海默病（AD）生物标志物以外的认知衰退的独特差异尚不清楚。在越南退伍军人的临床前队列中，我们研究了创伤后应激障碍（PTSD）症状严重程度、AD 的β-淀粉样蛋白（Aβ）和tau 生物标志物与两种广泛使用的筛查工具（简易精神状态检查（MMSE）和蒙特利尔认知评估（MoCA））认知表现变化之间的关系。分析表明，在调整 AD 生物标志物后，PTSD 症状严重程度与 MMSE（p < 0.04）和 MoCA（p < 0.024）的下降幅度更大，尤其是在 MoCA 的注意力量表和 MMSE 的记忆指数上。这些分析在经过多次比较校正后仍然成立。综上所述，PTSD 症状严重程度与认知衰退加速有关。随着成年人年龄的增长，治疗 PTSD 应被视为维持认知功能的重要手段。
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