Worms P, Martinez J, Briet C, Castro B, Biziere K
Eur J Pharmacol. 1986 Mar 4;121(3):395-401. doi: 10.1016/0014-2999(86)90260-8.
The behavioural effect of intrastriatally injected cholecystokinin sulphated octapeptide (CCK-8S), and its interactions with the antagonists Z-CCK-(27-32)NH2 and proglumide, were investigated in mice. When injected into the right striatum, CCK-8S (0.05-1 ng) induced contralateral rotations, as did the dopamine agonist apomorphine. Non-sulphated CCK-8 was inactive and sulphated desamino-CCK-7 was only weakly active in this respect. CCK-8S-induced turning was antagonized by co-injected Z-CCK-(27-32)NH2 (0.01-10 ng) or proglumide (0.1-1 micrograms), as well as by intraperitoneal injection of the neuroleptic drug haloperidol. These data suggest that CCK-8S may, in these conditions, stimulate dopamine-mediated neurotransmission, and that Z-CCK-(27-32)NH2, in addition to its peripheral effect, is also a very potent CCK antagonist at the striatal level.
研究了向小鼠纹状体内注射硫酸化八肽胆囊收缩素（CCK - 8S）的行为效应及其与拮抗剂Z - CCK - (27 - 32)NH2和丙谷胺的相互作用。当注射到右侧纹状体时，CCK - 8S（0.05 - 1纳克）诱导对侧旋转，多巴胺激动剂阿扑吗啡也有此作用。非硫酸化的CCK - 8在此方面无活性，硫酸化的去氨基CCK - 7在此方面仅有微弱活性。共注射Z - CCK - (27 - 32)NH2（0.01 - 10纳克）或丙谷胺（0.1 - 1微克）以及腹腔注射抗精神病药物氟哌啶醇均可拮抗CCK - 8S诱导的旋转。这些数据表明，在这些条件下CCK - 8S可能刺激多巴胺介导的神经传递，并且Z - CCK - (27 - 32)NH2除了具有外周效应外，在纹状体水平也是一种非常有效的CCK拮抗剂。
