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7,8-二羟基黄酮诱导恶性黑色素瘤细胞发生线粒体凋亡并下调神经节苷脂GD3的表达。

7,8-Dihydroxyflavone induces mitochondrial apoptosis and down-regulates the expression of ganglioside GD3 in malignant melanoma cells.

作者信息

Ju Won Seok, Seo Sang Young, Mun Seong-Eun, Kim Kyongtae, Yu Jin Ok, Ryu Jae-Sung, Kim Ji-Su, Choo Young-Kug

机构信息

Department of Biological Science, College of Natural Sciences, Wonkwang University, 460, Iksan-daero, Iksan-si, Jeollabuk-do, 54538, Republic of Korea.

Animal Biotechnology Division, Rural Development Administration, National Institute of Animal Science, 1500 Kongjwipatjwi-ro, Iseo-myeon, Wanju-gun, Jeonbuk, 55365, Republic of Korea.

出版信息

Discov Oncol. 2023 Mar 30;14(1):36. doi: 10.1007/s12672-023-00643-0.

DOI:10.1007/s12672-023-00643-0
PMID:36991237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10060447/
Abstract

Malignant melanoma is a skin cancer with poor prognosis and high resistance to conventional treatment. 7,8-dihydroxyflavone (7,8-DHF) has shown anti-carcinogenic, anti-inflammatory, anti-oxidant, and pharmacological effects in several types of cancer. However, the relationship between ganglioside expression and the anti-cancer effects of 7,8-DHF in melanoma is not fully understood. In the present study, 7,8-DHF exhibits specific anti-proliferation, anti-migration, and G2/M phase cell-cycle arrest effects on both melanoma cancer cell lines, and induces mitochondrial dysfunction and apoptosis, making it a potent candidate for anti-melanoma treatment. Furthermore, we confirmed that 7,8-DHF significantly reduces the expression levels of ganglioside GD3 and its synthase, which are known to be closely involved in carcinogenesis. Taken together, our findings suggest that 7,8-DHF may be a potent anti-cancer drug candidate for the treatment of malignant melanoma.

摘要

恶性黑色素瘤是一种预后较差且对传统治疗具有高抗性的皮肤癌。7,8 - 二羟基黄酮（7,8 - DHF）在几种类型的癌症中已显示出抗癌、抗炎、抗氧化和药理作用。然而，神经节苷脂表达与7,8 - DHF在黑色素瘤中的抗癌作用之间的关系尚未完全明确。在本研究中，7,8 - DHF对两种黑色素瘤癌细胞系均表现出特异性的抗增殖、抗迁移和G2/M期细胞周期阻滞作用，并诱导线粒体功能障碍和细胞凋亡，使其成为抗黑色素瘤治疗的有力候选药物。此外，我们证实7,8 - DHF显著降低了神经节苷脂GD3及其合酶的表达水平，已知它们与致癌作用密切相关。综上所述，我们的研究结果表明7,8 - DHF可能是治疗恶性黑色素瘤的一种有效的抗癌候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/2e27685550c7/12672_2023_643_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/eb9db2ef2a16/12672_2023_643_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/c688dd86ee15/12672_2023_643_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/97622f6c9b30/12672_2023_643_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/25f81176be8e/12672_2023_643_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/fa9c4a602293/12672_2023_643_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/2e27685550c7/12672_2023_643_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/eb9db2ef2a16/12672_2023_643_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/c688dd86ee15/12672_2023_643_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/97622f6c9b30/12672_2023_643_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/25f81176be8e/12672_2023_643_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/fa9c4a602293/12672_2023_643_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/10060447/2e27685550c7/12672_2023_643_Fig6_HTML.jpg

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