Sinha Hikim A P
Exp Mol Pathol. 1986 Apr;44(2):190-6. doi: 10.1016/0014-4800(86)90069-9.
The effect of PMHI on the epididymis and accessory sex glands (ventral prostate, seminal vesicle, and coagulating gland) was studied in a wild rodent, the bandicoot rat. Animals were given a single subcutaneous injection of PMHI (150 mg/kg body wt) and were killed 2, 10, or 30 days later. Treatment of PMHI resulted in severe alterations in the epididymis of the bandicoot rat with no apparent effect on accessory sex glands except for a transitory decrease in epithelial height of the seminal vesicle and in peripheral acini of the ventral prostate. Changes in the epididymis included a marked involution of the caput, Zone I in particular, formation of sperm granulomata, and the distension of the "clear" cells in the caudal portion of the duct. Sperms progressively disappeared from the lumen and by Day 30, the cauda epididymis became completely azoospermic. It appears that the epididymal lesions produced by this compound may play a contributory role to induce infertility in the bandicoot rat.
在野生啮齿动物袋狸大鼠中研究了PMHI对附睾和附属性腺（腹侧前列腺、精囊和凝固腺）的影响。给动物皮下注射一次PMHI（150毫克/千克体重），并在2、10或30天后处死。PMHI处理导致袋狸大鼠附睾出现严重改变，对附属性腺无明显影响，只是精囊上皮高度和腹侧前列腺外周腺泡有短暂降低。附睾的变化包括头部明显退化，尤其是I区，形成精子肉芽肿，以及输精管尾部“透明”细胞扩张。精子逐渐从管腔中消失，到第30天，附睾尾部完全无精子。看来这种化合物产生的附睾病变可能在诱导袋狸大鼠不育方面起促成作用。
