Sinha Hikim A P
Int J Androl. 1985 Oct;8(5):393-402. doi: 10.1111/j.1365-2605.1985.tb00852.x.
The anti-testicular action of PMHI was investigated in a wild rodent, the bandicoot rat. Bandicoots were given a single subcutaneous injection of this compound at a dose of 150 mg/kg and were killed 2, 10, or 30 days later. PMHI induced marked and rapid testicular regression with complete arrest of spermatogenesis by day 10 such that the seminiferous tubules contained only a ring of Sertoli cells with few spermatogonia. This was also reflected by a severe depletion of the number of sperm in the cauda epididymis. However, by day 30 after PMHI injection, testicular histology indicated restoration of spermatogenesis in parallel with the time schedule of germ cell development. The results indicate that PHMI produces a reversible anti-spermatogenic effect in the bandicoot rat which appears to be time dependent.
在野生啮齿动物印度地鼠身上研究了PMHI的抗睾丸作用。给印度地鼠皮下注射一次剂量为150mg/kg的该化合物，然后在2天、10天或30天后处死。到第10天时，PMHI引起明显且迅速的睾丸退化，精子发生完全停止，使得曲细精管仅含有一层支持细胞环，几乎没有精原细胞。这也反映在附睾尾部精子数量的严重减少上。然而，在注射PMHI后第30天时，睾丸组织学显示精子发生恢复，与生殖细胞发育的时间进程同步。结果表明，PHMI在印度地鼠中产生可逆的抗生精作用，且这种作用似乎具有时间依赖性。
