甲基汞导致小鼠胎儿星形胶质细胞表面电荷改变：用阳离子铁蛋白进行的超微结构研究

Surface charge alterations in mouse fetal astrocytes due to methyl mercury: an ultrastructural study with cationized ferritin.

作者信息

Peckham N H, Choi B H

出版信息

Exp Mol Pathol. 1986 Apr;44(2):230-4. doi: 10.1016/0014-4800(86)90073-0.

Abstract

A brief exposure of low dose methylmercuric chloride to monolayer cultures of mouse fetal astrocytes caused a marked shift in the distribution of anionic groups on the surface membrane as evidenced by irregular disruption of cationized ferritin. It is suggested that one of the earliest changes following methyl mercury exposure in embryonic astrocytes includes alterations in the surface charge which may in turn trigger cascading toxic actions of methyl mercury in the developing brain.

摘要

低剂量甲基汞氯化物对小鼠胎儿星形胶质细胞单层培养物的短暂暴露，导致表面膜上阴离子基团分布发生明显变化，阳离子铁蛋白的不规则破坏证明了这一点。有人提出，胚胎星形胶质细胞暴露于甲基汞后最早出现的变化之一包括表面电荷的改变，这反过来可能引发甲基汞在发育中的大脑中的级联毒性作用。