Chapman L, Chan H M
Center for Indigenous Peoples' Nutrition and the Environment and the School of Dietetics and Human Nutrition, Macdonald Campus at McGill University, Quebec, Canada.
Environ Health Perspect. 2000 Mar;108 Suppl 1(Suppl 1):29-56. doi: 10.1289/ehp.00108s129.
This article reviews progress in the research of methyl mercury (MeHg) and nutrient interactions during the past two decades. Special emphasis is placed on the following three major areas: a) effects on kinetics, b) effects on toxicity, and c) possible mechanisms. Dietary information is not usually collected in most epidemiologic studies examining of the effects of MeHg exposure. However, inconsistency of the MeHg toxicity observed in different populations is commonly attributed to possible effects of dietary modulation. Even though the mechanisms of interaction have not been totally elucidated, research in nutritional toxicology has provided insights into the understanding of the effects of nutrients on MeHg toxicity. Some of this information can be readily incorporated into the risk assessment of MeHg in the diets of fish-eating populations. It is also clear that there is a need for more studies designed specifically to address the role of nutrition in the metabolism and detoxification of MeHg. It is also important to collect more detailed dietary information in future epidemiologic studies of MeHg exposure.
本文回顾了过去二十年中甲基汞（MeHg）与营养素相互作用的研究进展。特别强调以下三个主要领域：a）对动力学的影响，b）对毒性的影响，以及c）可能的机制。在大多数研究甲基汞暴露影响的流行病学研究中，通常不会收集饮食信息。然而，在不同人群中观察到的甲基汞毒性不一致通常归因于饮食调节的可能影响。尽管相互作用的机制尚未完全阐明，但营养毒理学的研究为理解营养素对甲基汞毒性的影响提供了见解。其中一些信息可以很容易地纳入对食鱼人群饮食中甲基汞的风险评估。同样明显的是，需要开展更多专门针对营养在甲基汞代谢和解毒中的作用的研究。在未来关于甲基汞暴露的流行病学研究中收集更详细的饮食信息也很重要。
