Hirsch I, Gibbons W E, Lipshultz L I, Rossavik K K, Young R L, Poindexter A N, Dodson M G, Findley W E
Fertil Steril. 1986 May;45(5):659-64. doi: 10.1016/s0015-0282(16)49338-6.
The data from 83 consecutive in vitro fertilization-embryo transfer cycles were examined with emphasis on the presence of subfertile male parameters, including abnormal sperm density, motility, morphologic features, or an abnormal result in the sperm penetration assay (zona-free hamster ova penetration). There were 25 cycles (21 couples) in which there was a solitary or coexistent abnormal male factor. The presence of a male factor was associated with a lower fertilization rate and fewer embryos transferred. Statistically important reductions in the fertilization rate occurred with reduced sperm density and abnormal motility, but not with abnormal morphologic features. The parameter that was most significantly associated with human ova fertilizability was the ability to exceed two penetrations per egg in the sperm penetration assay.
对连续83个体外受精-胚胎移植周期的数据进行了检查，重点关注男性生育力低下参数的存在情况，包括精子密度异常、活力、形态特征，或精子穿透试验（无透明带仓鼠卵穿透试验）结果异常。有25个周期（21对夫妇）存在单一或并存的男性因素异常。男性因素的存在与较低的受精率和较少的移植胚胎数相关。精子密度降低和活力异常会导致受精率在统计学上有显著降低，但形态特征异常则不会。与人类卵子受精能力最显著相关的参数是在精子穿透试验中每个卵子超过两次穿透的能力。
