基于外差干涉的酶葡萄糖纤维传感器用于葡萄糖浓度测量。
Enzymatic Glucose Fiber Sensor for Glucose Concentration Measurement with a Heterodyne Interferometry.
机构信息
Department of Electro-Optical Engineering, National United University, No. 2 Lienda, Miaoli 36063, Taiwan.
Department of Photonics Engineering, Yuan Ze University, 135, Yuan-Tung Road, Taoyuan City 32003, Taiwan.
出版信息
Sensors (Basel). 2023 Mar 9;23(6):2990. doi: 10.3390/s23062990.
In this study, we developed a glucose fiber sensor incorporating heterodyne interferometry to measure the phase difference produced by the chemical reaction between glucose and glucose oxidase (GOx). Both theoretical and experimental results showed that the amount of phase variation is inversely proportional to glucose concentration. The proposed method provided a linear measurement range of the glucose concentration from 10 mg/dL to 550 mg/dL. The experimental results indicated that the sensitivity is proportional to the length of the enzymatic glucose sensor, and the optimum resolution can be obtained at a sensor length of 3 cm. The optimum resolution of the proposed method is better than 0.6 mg/dL. Moreover, the proposed sensor demonstrates good repeatability and reliability. The average relative standard deviation (RSD) is better than 10% and satisfied the minimum requirement for point-of-care devices.
在这项研究中，我们开发了一种结合外差干涉测量法的葡萄糖纤维传感器，用于测量葡萄糖和葡萄糖氧化酶（GOx）之间化学反应产生的相位差。理论和实验结果均表明，相位变化量与葡萄糖浓度成反比。所提出的方法提供了从 10mg/dL 到 550mg/dL 的葡萄糖浓度线性测量范围。实验结果表明，灵敏度与酶葡萄糖传感器的长度成正比，在传感器长度为 3cm 时可以获得最佳分辨率。所提出方法的最佳分辨率优于 0.6mg/dL。此外，所提出的传感器表现出良好的重复性和可靠性。平均相对标准偏差（RSD）优于 10%，满足即时检测设备的最低要求。
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