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寨卡病毒的媒介效能因在玛瑙斯的“人源起源地域”而异:对一个巴西亚马逊地区地方性城市的研究。

Vector Competence for Zika Virus Changes Depending on the 's Region of Origin in Manaus: A Study of an Endemic Brazilian Amazonian City.

机构信息

Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus 69040-000, Amazonas, Brazil.

Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Amazonas, Brazil.

出版信息

Viruses. 2023 Mar 17;15(3):770. doi: 10.3390/v15030770.

DOI:10.3390/v15030770
PMID:36992479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10058289/
Abstract

Zika virus (ZIKV) is transmitted to humans by the infectious bite of mosquitoes such as . In a city, the population control of mosquitoes is carried out according to alerts generated by different districts via the analysis of the mosquito index. However, we do not know whether, besides mosquito abundance, the susceptibility of mosquitoes could also diverge among districts and thus impact the dissemination and transmission of arboviruses. After a viremic blood meal, the virus must infect the midgut, disseminate to tissues, and reach the salivary gland to be transmitted to a vertebrate host. This study evaluated the patterns of ZIKV infection in the field populations of a city. The disseminated infection rate, viral transmission rate, and transmission efficiency were measured using quantitative PCR at 14 days post-infection. The results showed that all populations had individuals susceptible to ZIKV infection and able to transmit the virus. The infection parameters showed that the geographical area of origin of the influences its vector competence for ZIKV transmission.

摘要

寨卡病毒(ZIKV)通过 等感染性蚊子的叮咬传播给人类。在城市中,根据不同地区通过蚊虫指数分析产生的警报,对蚊子进行种群控制。然而,我们不知道除了蚊子的丰度之外,蚊子的易感性是否也会在不同地区存在差异,从而影响虫媒病毒的传播和传播。在血餐感染后,病毒必须感染中肠,扩散到组织,并到达唾液腺才能传播给脊椎动物宿主。本研究评估了一个城市野外种群中 ZIKV 感染的模式。在感染后 14 天,通过定量 PCR 测量了病毒传播率、病毒传播率和传播效率。结果表明,所有种群都有易感染 ZIKV 的个体,并且能够传播病毒。感染参数表明, 的地理来源地区影响其对 ZIKV 传播的媒介能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eee/10058289/9f669eaf4b6c/viruses-15-00770-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eee/10058289/497b8d8bf5a7/viruses-15-00770-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eee/10058289/9f669eaf4b6c/viruses-15-00770-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eee/10058289/497b8d8bf5a7/viruses-15-00770-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eee/10058289/9f669eaf4b6c/viruses-15-00770-g002.jpg

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本文引用的文献

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Viruses. 2021 Dec 23;14(1):20. doi: 10.3390/v14010020.
2
High resolution proteomics of Aedes aegypti salivary glands infected with either dengue, Zika or chikungunya viruses identify new virus specific and broad antiviral factors.登革热、寨卡和基孔肯雅热病毒感染埃及伊蚊唾液腺的高分辨率蛋白质组学研究鉴定了新的病毒特异性和广谱抗病毒因子。
Sci Rep. 2021 Dec 8;11(1):23696. doi: 10.1038/s41598-021-03211-0.
3
Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city.
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4
Different populations of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) from Central Africa are susceptible to Zika virus infection.来自中非的埃及伊蚊和白纹伊蚊(双翅目:蚊科)的不同种群易感染 Zika 病毒。
PLoS Negl Trop Dis. 2020 Mar 23;14(3):e0008163. doi: 10.1371/journal.pntd.0008163. eCollection 2020 Mar.
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