Instituto de Pequisa Clínicas Carlos Borborema, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus.
Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus.
J Infect Dis. 2018 Jul 13;218(4):563-571. doi: 10.1093/infdis/jiy196.
Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses.
A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice.
A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host.
This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.
一些热带城市对埃及伊蚊和登革热病毒（DENV）流行较为宽容，并且允许寨卡病毒（ZIKV）在同一地区入侵和传播。生活在虫媒病毒流行地区的人同时感染了≥2 种虫媒病毒。
从巴西亚马逊州首府玛瑙斯采集埃及伊蚊，使其感染循环流行株的 DENV 和 ZIKV。让感染的蚊叮咬 BALB/c 小鼠。
来自玛瑙斯的埃及伊蚊对 DENV 和 ZIKV 的单感染和混合感染均具有高度易感性，并且能够通过叮咬传播这两种病原体。混合感染强烈影响媒介效能，有利于 ZIKV 向脊椎动物宿主传播。
这一发现表明埃及伊蚊是 ZIKV 的有效传播媒介，并且 ZIKV 将优先由混合感染的埃及伊蚊传播。在媒介种群中的混合感染应被视为一个新的重要流行病学因素，并可能构成一个重大的公共卫生挑战。
