Tamaki Y, Oda S, Kameyama Y
Dev Psychobiol. 1986 Jan;19(1):67-77. doi: 10.1002/dev.420190108.
Postural control skills and quadrupedal locomotor pattern in infant rolling mice, a neurological mutant, were observed in the following situations: hindlimb support when suspended, rope descent, narrow path traverse, quadrupedal locomotion on an inclined corridor, and swimming behavior when entirely submerged. Until the second week of age, rolling mice developed primitive responses similar to, or somewhat slower than, their unaffected littermates, but failed to show mature adaptive and coordinated movements from Days 16-18 onward in hinblimb support and rope descent tests. The gait was broadbased and they frequently lurched, rolled over on the side in the narrow-path and incline situations. Also, swimming behavior was extremely clumsy with varying degrees of disturbed rhythm and inconsistent movement of hindlimb paddling. These findings might result from an immature development of hindlimb muscle tonus control system and distortion of smooth and orderly sequence of hindlimb muscular contractions which characterize skillful quadrupedal locomotion.
悬吊时的后肢支撑、绳索下降、窄道穿越、倾斜通道上的四足运动以及完全浸没时的游泳行为。直到两周龄，滚动小鼠表现出与未受影响的同窝小鼠相似或稍慢的原始反应，但在第16 - 18天之后的后肢支撑和绳索下降测试中未能表现出成熟的适应性和协调性运动。步态宽阔，在窄道和倾斜情况下它们经常摇晃、侧身翻滚。此外，游泳行为极其笨拙，后肢划水节奏不同程度地紊乱且动作不一致。这些发现可能源于后肢肌肉张力控制系统发育不成熟以及后肢肌肉收缩的平滑有序序列扭曲，而这种序列是熟练四足运动的特征。
