Erginel Basak, Karli Gokce, Baziki Kadir, Berker Neslihan, Keskin Erbug, Gün Soysal Feryal
Pediatric Surgery, Istanbul University School of Medicine, Istanbul, TUR.
Pathology, Istanbul University School of Medicine, Istanbul, TUR.
Cureus. 2023 Mar 27;15(3):e36733. doi: 10.7759/cureus.36733. eCollection 2023 Mar.
Objective Our study aimed to retrospectively evaluate -associated appendicitis cases and compare them with acute appendicitis cases in terms of parameters such as the neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP)-to-lymphocyte ratio (CLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). We primarily aimed to evaluate the utility of SII in the differential diagnosis of -associated appendicitis. Methods The appendectomy specimens of pediatric patients who were operated on for acute appendicitis between June 2016 and August 2022 were retrospectively evaluated. -associated appendicitis cases were included for analysis. All patients were evaluated regarding age, gender, blood count, surgery, and pathology reports. Pathology reports were evaluated for the presence of histological signs of acute appendicitis. The patients were classified into an -associated appendicitis group and a regular acute appendicitis group. CRP, white blood cell (WBC), red cell distribution width (RDW), neutrophils, lymphocytes, NLR, monocytes, eosinophils, platelet (PLT), PLR, CLR, and SII values were compared between the two groups. Results Eleven cases of -associated appendicitis were identified out of 430 total cases (2.55%) examined. The mean age of the group with acute appendicitis was 12.83 ±3.16 years, while the mean age of the group with -associated appendicitis was 8.55 ±2.54 years. There was no statistically significant difference in terms of CRP, WBC, RDW, lymphocytes, neutrophils, NLR, monocytes, eosinophils, PLT, PLR, and CLR values between the two groups (p>0.05). However, when the SII values of the participants were analyzed, it was observed that the SII values of the participants in the regular appendicitis group were significantly higher than those of the participants in the group (p<0.05). Among the 11 -associated appendicitis patients, seven appendectomy specimens revealed no inflammation and were regarded as negative appendectomy (63.63%). Conclusion This is the first study to demonstrate the utility of preoperative SII evaluation in -associated appendicitis. SII is a simple, easy-to-calculate indicator of -associated appendicitis and aids in the preoperative differential diagnosis of acute appendicitis.
目的 本研究旨在回顾性评估[具体疾病名称未给出]相关性阑尾炎病例，并在中性粒细胞与淋巴细胞比值（NLR）、C反应蛋白（CRP）与淋巴细胞比值（CLR）、血小板与淋巴细胞比值（PLR）以及全身免疫炎症指数（SII）等参数方面将其与急性阑尾炎病例进行比较。我们主要旨在评估SII在[具体疾病名称未给出]相关性阑尾炎鉴别诊断中的效用。方法 回顾性评估2016年6月至2022年8月间因急性阑尾炎接受手术的儿科患者的阑尾切除标本。纳入[具体疾病名称未给出]相关性阑尾炎病例进行分析。对所有患者的年龄、性别、血常规、手术及病理报告进行评估。病理报告评估是否存在急性阑尾炎的组织学征象。将患者分为[具体疾病名称未给出]相关性阑尾炎组和普通急性阑尾炎组。比较两组间的CRP、白细胞（WBC）、红细胞分布宽度（RDW）、中性粒细胞、淋巴细胞、NLR、单核细胞、嗜酸性粒细胞、血小板（PLT）、PLR、CLR及SII值。结果 在总共430例接受检查的病例中，确定了11例[具体疾病名称未给出]相关性阑尾炎病例（2.55%）。急性阑尾炎组的平均年龄为12.83±3.16岁，而[具体疾病名称未给出]相关性阑尾炎组的平均年龄为8.55±2.54岁。两组间在CRP、WBC、RDW、淋巴细胞、中性粒细胞、NLR、单核细胞、嗜酸性粒细胞、PLT、PLR及CLR值方面无统计学显著差异（p>0.05）。然而，当分析参与者的SII值时，观察到普通阑尾炎组参与者的SII值显著高于[具体疾病名称未给出]相关性阑尾炎组参与者的SII值（p<0.05）。在11例[具体疾病名称未给出]相关性阑尾炎患者中，7例阑尾切除标本未显示炎症，被视为阴性阑尾切除术（63.63%）。结论 这是第一项证明术前SII评估在[具体疾病名称未给出]相关性阑尾炎中的效用的研究。SII是[具体疾病名称未给出]相关性阑尾炎的一个简单、易于计算的指标，有助于急性阑尾炎的术前鉴别诊断。
