School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom.
Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Public Health. 2023 Mar 13;11:1081843. doi: 10.3389/fpubh.2023.1081843. eCollection 2023.
Sarcopenia and low hemoglobin level are common in older adults. Few studies have evaluated the association between hemoglobin level and sarcopenia and with inconsistent findings. The multifaceted effects of sarcopenia on the human body and the high prevalence of anemia in the Chinese population make it necessary to explore the association between the two.
Using the China Health and Retirement Longitudinal Study (CHARLS), we explored the association between hemoglobin with sarcopenia and its components in the Chinese population aged 60 and above. Multivariate logistic and Cox proportional hazards models were constructed to examine the association of hemoglobin level with sarcopenia and sarcopenia components in individuals aged 60 years or above. The subgroup analysis covered residence, body mass index level, drinking status, and smoking status were conducted. The possible difference of associations between sexes was also explored.
With a total of 3,055 people, the hemoglobin concentration in people without sarcopenia, possible sarcopenia, and sarcopenia are 14.34 ± 2.22, 14.64 ± 2.27, and 13.58 ± 2.02 g/dl, respectively. Cross-sectional analysis showed strong evidence that hemoglobin was negatively associated with sarcopenia [Odds Ratio (OR) = 0.95, 95% Confidence Interval (CI): 0.90-0.99] and low height-adjusted appendicular skeletal muscle mass (OR = 0.91, 95% CI: 0.86-0.97). On average, a per 1 g/dl higher hemoglobin level was associated with 5% lower odds of sarcopenia (OR = 0.95, 95% CI: 0.90-0.98). The cohort study of 1,022 people demonstrated a statistically significant negative association of hemoglobin level with low physical performance [Hazard Ratio (HR) = 0.92, 95% CI: 0.85-0.99], merely with sarcopenia (HR = 0.92, 95% CI: 0.84-1.00) and skeletal muscle mass (HR = 0.95, 95% CI: 0.80-1.00). Sex-specific analysis suggested hemoglobin's association with sarcopenia, muscle mass, and physical performance in all sexes, with weaker magnitudes in females. Hemoglobin in urban residents and people with high body mass index (BMI) has a larger magnitude of the negative association with sarcopenia.
Hemoglobin level associates with sarcopenia, muscle mass, and physical performance in the Chinese population aged 60 and above, with sex-specific, residence-specific, and BMI-specific effects.
肌少症和低血红蛋白水平在老年人中很常见。很少有研究评估血红蛋白水平与肌少症之间的关系，且结果不一致。肌少症对人体的多方面影响以及中国人口中贫血的高患病率使得有必要探讨两者之间的关系。
本研究使用中国健康与养老追踪调查（CHARLS），探讨了血红蛋白与中国 60 岁及以上人群肌少症及其组成部分之间的关系。构建了多变量逻辑和 Cox 比例风险模型，以检验血红蛋白水平与 60 岁及以上个体的肌少症和肌少症成分之间的关联。进行了居住地、体重指数水平、饮酒状况和吸烟状况的亚组分析。还探讨了性别之间关联的可能差异。
共有 3055 人，无肌少症、可能肌少症和肌少症患者的血红蛋白浓度分别为 14.34±2.22、14.64±2.27 和 13.58±2.02 g/dl。横断面分析显示，血红蛋白与肌少症[比值比（OR）=0.95，95%置信区间（CI）：0.90-0.99]和低身高调整后的四肢骨骼肌质量[比值比（OR）=0.91，95%置信区间（CI）：0.86-0.97]呈强负相关。平均而言，血红蛋白水平每升高 1 g/dl，肌少症的可能性降低 5%（OR=0.95，95%CI：0.90-0.98）。对 1022 人的队列研究表明，血红蛋白水平与较低的身体表现呈统计学显著负相关[风险比（HR）=0.92，95%置信区间（CI）：0.85-0.99]，仅与肌少症（HR=0.92，95%CI：0.84-1.00）和骨骼肌质量（HR=0.95，95%CI：0.80-1.00）相关。性别特异性分析表明，血红蛋白与所有性别的肌少症、肌肉质量和身体表现相关，女性的相关性较弱。城市居民和高体重指数（BMI）人群的血红蛋白与肌少症的负相关程度更大。
血红蛋白水平与中国 60 岁及以上人群的肌少症、肌肉质量和身体表现相关，具有性别特异性、居住地特异性和 BMI 特异性的影响。
