Department of Endocrinology, Guiyang Fourth People's Hospital, Guiyang, Gui Zhou Province, China.
PLoS One. 2023 Oct 20;18(10):e0292654. doi: 10.1371/journal.pone.0292654. eCollection 2023.
Limited research exists regarding the relationship between fasting plasma C-peptide levels and sarcopenia. As a result, our study aimed to examine this association in elderly Chinese diabetic patients. This cross-sectional study included 288 elderly patients with diabetes mellitus from the Fourth People's Hospital in Guiyang who were enrolled prospectively between March 2020 and February 2023. The independent variable of interest was fasting plasma C-peptide, while the dependent variable was sarcopenia. Data on several covariates, including demographic factors, lifestyle habits, co-morbidities, anthropometric indicators, and laboratory indicators, were also collected. Of the 288 participants, 27.43% (79/288) had sarcopenia. After adjusting for potential confounding variables, we found a U-shaped association between fasting plasma C-peptide levels and sarcopenia, with inflection points identified at approximately 774 pmol/L and 939 mmol/L. Within the range of 50-744 pmol/L, each 100 pmol/L increase in CysC was associated with a 37% decrease in the odds of sarcopenia (odds ratio [OR], 0.63; 95% confidence interval [CI], 0.49 to 0.83; P < 0.001). Additionally, within the range of 939-1694 pmol/L, each 100 pmol/L increase in fasting plasma C-peptide was associated with a 76% increase in the odds of sarcopenia (odds ratio [OR], 1.76; 95% confidence interval [CI], 1.11 to 2.81; P = 0.017). Our study revealed a U-shaped association between fasting plasma C-peptide levels and the likelihood of sarcopenia, with lower risk in the range of 774-939 pmol/L. These findings may assist in the development of more effective prevention and treatment strategies for sarcopenia in elderly diabetic patients.
关于空腹血浆 C 肽水平与肌肉减少症之间的关系，研究有限。因此，我们的研究旨在检查贵阳第四人民医院的老年糖尿病患者中这种关联。这项横断面研究纳入了 2020 年 3 月至 2023 年 2 月期间前瞻性招募的 288 名老年糖尿病患者。感兴趣的自变量是空腹血浆 C 肽，因变量是肌肉减少症。还收集了包括人口统计学因素、生活方式习惯、合并症、人体测量指标和实验室指标在内的多个协变量的数据。在 288 名参与者中，27.43%（79/288）患有肌肉减少症。在校正了潜在的混杂变量后，我们发现空腹血浆 C 肽水平与肌肉减少症之间呈 U 型关联，拐点约为 774 pmol/L 和 939 mmol/L。在 50-744 pmol/L 范围内，CysC 每增加 100 pmol/L，肌肉减少症的几率降低 37%（优势比[OR]，0.63；95%置信区间[CI]，0.49 至 0.83；P<0.001）。此外，在 939-1694 pmol/L 范围内，空腹血浆 C 肽每增加 100 pmol/L，肌肉减少症的几率增加 76%（优势比[OR]，1.76；95%置信区间[CI]，1.11 至 2.81；P=0.017）。我们的研究揭示了空腹血浆 C 肽水平与肌肉减少症可能性之间呈 U 型关联，在 774-939 pmol/L 范围内风险较低。这些发现可能有助于为老年糖尿病患者的肌肉减少症制定更有效的预防和治疗策略。
