Sengupta Anirban, Mishra Arabinda, Wang Feng, Chen Li, Gore John
Vanderbilt University Medical Center.
Res Sq. 2023 Mar 14:rs.3.rs-2389151. doi: 10.21203/rs.3.rs-2389151/v1.
Functional MRI studies of the brain have shown that blood-oxygenation-level-dependent (BOLD) signals are robustly detectable not only in gray matter (GM) but also in white matter (WM). Here, we report the detection and characteristics of BOLD signals in WM of spinal cord (SC) of squirrel monkeys. Tactile stimulus-evoked BOLD signal changes were detected in the ascending sensory tracts of SC using a General-Linear Model (GLM) as well as Independent Component Analysis (ICA). ICA of resting state signals identified coherent fluctuations from eight WM hubs which correspond closely with known anatomical locations of SC WM tracts. Resting state analyses showed that the WM hubs exhibited correlated signal fluctuations within and between SC segments in specific patterns that correspond well with the known neurobiological functions of WM tracts in SC. Overall, these findings suggest WM BOLD signals in SC show similar features as GM both at baseline and under stimulus conditions.
大脑的功能磁共振成像研究表明，不仅在灰质（GM）中，而且在白质（WM）中都能可靠地检测到血氧水平依赖（BOLD）信号。在此，我们报告松鼠猴脊髓（SC）白质中BOLD信号的检测及其特征。使用通用线性模型（GLM）以及独立成分分析（ICA），在SC的上行感觉束中检测到触觉刺激诱发的BOLD信号变化。静息状态信号的ICA识别出八个白质枢纽的相干波动，这些波动与SC白质束的已知解剖位置密切对应。静息状态分析表明，白质枢纽在SC节段内和节段间表现出相关的信号波动，其特定模式与SC中白质束的已知神经生物学功能高度吻合。总体而言，这些发现表明，SC中的白质BOLD信号在基线和刺激条件下均表现出与灰质相似的特征。
