选择性腺苷A2A受体激动剂可能改变心肌灌注成像。
Selective Adenosine A2A Agonists May Change Myocardial Perfusion Imaging.
作者信息
Takehana Kazuya
机构信息
Division of Cardiology, Department of Medicine II, Kansai Medical University, Osaka, Japan.
出版信息
Ann Nucl Cardiol. 2021;7(1):63-66. doi: 10.17996/anc.21-00147. Epub 2021 Aug 31.
Abstract
In recent years, the requirement for pharmacological stress myocardial perfusion imaging (SPECT) has increased, and adenosine stress testing is now the mainstream. Selective adenosine A2A receptor agonists will be applied clinically in the future. By selectively activating only A2A receptors, it can reduce complications such as bronchospasm, hypotension, and bradycardia, which have been problems with adenosine stress tests. In addition, since this drug can be administered in bolus injection, it has the advantage of being able to perform the test at one root.
摘要
近年来，药理应激心肌灌注显像（SPECT）的需求有所增加，腺苷负荷试验目前是主流。选择性腺苷A2A受体激动剂未来将应用于临床。通过仅选择性激活A2A受体，它可以减少诸如支气管痉挛、低血压和心动过缓等并发症，这些一直是腺苷负荷试验存在的问题。此外，由于这种药物可以静脉推注给药，它具有能够一次完成检查的优势。
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2
Comparison of the Safety of Adenosine and Regadenoson in Patients Undergoing Outpatient Cardiac Stress Testing.
Pharmacotherapy. 2015 Dec;35(12):1117-23. doi: 10.1002/phar.1669.
3
Regadenoson-induced coronary vasospasm resulting in severe reversible perfusion defects and transient ischemic dilation on SPECT stress myocardial perfusion imaging.
J Nucl Cardiol. 2016 Aug;23(4):843-5. doi: 10.1007/s12350-015-0275-4. Epub 2015 Sep 18.
4
Coupling of P2Y receptors to G proteins and other signaling pathways.
Wiley Interdiscip Rev Membr Transp Signal. 2012 Nov-Dec;1(6):789-803. doi: 10.1002/wmts.62.
5
Asystole following regadenoson infusion in stable outpatients.
J Nucl Cardiol. 2014 Oct;21(5):862-8. doi: 10.1007/s12350-014-9898-0. Epub 2014 May 31.
6
2013 American Society of Nuclear Cardiology / MedAxiom Nuclear Survey.
J Nucl Cardiol. 2014 Apr;21 Suppl 1:5-88. doi: 10.1007/s12350-014-9862-z.
7
ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons.
J Am Coll Cardiol. 2014 Feb 4;63(4):380-406. doi: 10.1016/j.jacc.2013.11.009. Epub 2013 Dec 16.
8
Cardiovascular adenosine receptors: expression, actions and interactions.
Pharmacol Ther. 2013 Oct;140(1):92-111. doi: 10.1016/j.pharmthera.2013.06.002. Epub 2013 Jun 10.
9
Regadenoson: review of its established role in myocardial perfusion imaging and emerging applications.
Cardiol Rev. 2013 Jan-Feb;21(1):42-8. doi: 10.1097/CRD.0b013e3182613db6.
10
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