Yu Jiayi, Zhang Yu, Liu Zheran, He Yan, Pei Yiyan, Zhang Renjie, Peng Xingchen, Fang Fang
School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Front Neurol. 2023 Mar 13;14:1036387. doi: 10.3389/fneur.2023.1036387. eCollection 2023.
Smoking is associated with increased mortality in patients with cancer. However, there are limited data on the impact of smoking on the survival of patients with brain metastases. Therefore, this study aimed to evaluate whether smoking was associated with survival and whether smoking cessation was beneficial to these patients.
This study used lung cancer with a brain metastasis cohort of the West China Hospital of Sichuan University from 2013 to 2021. Patients were stratified according to smoking history; the distribution, clinical characteristics, and survival data of each group were estimated. Kaplan-Meier analysis and risk analysis were performed for the survival endpoint.
Of the 2,647 patients included in the analysis, the median age was 57.8 years, and 55.4% were men. Among them, 67.1% had no smoking history, 18.9% still smoked, and 14% reported quitting smoking. Compared with never smokers, current smokers [HR, 1.51 (95% CI, 1.35-1.69), < 0.01] and former smokers [HR, 1.32 (95% CI, 1.16-1.49), <0.01] had an increased risk of death. However, quitting smoking was not associated with improved survival [HR, 0.90 (95% CI, 0.77-1.04), = 0.16]. The overall survival increased with the increase of smoking cessation years.
In lung cancer patients with brain metastases, smoking was associated with an increased risk of death, but quitting smoking was not associated with improved survival.
吸烟与癌症患者死亡率增加有关。然而，关于吸烟对脑转移瘤患者生存影响的数据有限。因此，本研究旨在评估吸烟是否与生存相关，以及戒烟是否对这些患者有益。
本研究使用了四川大学华西医院2013年至2021年肺癌合并脑转移瘤队列。根据吸烟史对患者进行分层；估计每组的分布、临床特征和生存数据。对生存终点进行Kaplan-Meier分析和风险分析。
纳入分析的2647例患者中，中位年龄为57.8岁，男性占55.4%。其中，67.1%无吸烟史，18.9%仍在吸烟，14%报告已戒烟。与从不吸烟者相比，当前吸烟者[风险比（HR），1.51（95%置信区间[CI]，1.35 - 1.69），P < 0.01]和既往吸烟者[HR，1.32（95% CI，1.16 - 1.49），P < 0.01]死亡风险增加。然而，戒烟与生存改善无关[HR，0.90（95% CI，0.77 - 1.04），P = 0.16]。总生存期随戒烟年限增加而延长。
在肺癌合并脑转移瘤患者中，吸烟与死亡风险增加相关，但戒烟与生存改善无关。
