Lee Yoo Jeong, Hwang In Cheol, Ahn Hong Yup
Department of Family Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
Department of Family Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
Heliyon. 2023 Mar 18;9(3):e14650. doi: 10.1016/j.heliyon.2023.e14650. eCollection 2023 Mar.
Given the impact of oxidative imbalance on the development of airway pathologies, this study was undertaken to investigate the association between oxidative balance (OB) scores and lung function in the adult Korean population.
Data of 17,368 adults with available OB scores and pulmonary function test results were extracted from the 2013-2019 Korean National Health and Nutrition Examination Surveys. Multivariable logistic regression models were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for reduced forced expiratory volume in 1 s (FEV) and forced vital capacity (FVC) per 1-point decrease in OB score. Dose dependent association of reduced lung function with OB scores was also investigated.
Males, low-income subjects, individuals with comorbidities, and those with reduced pulmonary function had lower OB scores (representing oxidative balance). Overall, the association between oxidative imbalance and reduced lung function was remarkable in FVC than FEV (OR [95% CI], 1.06 [1.04-1.07] vs. 1.03 [1.02-1.04]; both p < 0.001). Linear relationships between the level of reduced lung function and OB scores were significantly noted (p for trend<0.001 in both FEV and FVC).
Our findings suggest that oxidative imbalance is associated with reduced pulmonary function.
鉴于氧化失衡对气道疾病发展的影响，本研究旨在调查韩国成年人群中氧化平衡（OB）评分与肺功能之间的关联。
从2013 - 2019年韩国国家健康与营养检查调查中提取了17368名有可用OB评分和肺功能测试结果的成年人的数据。使用多变量逻辑回归模型计算OB评分每降低1分，1秒用力呼气量（FEV）和用力肺活量（FVC）降低的比值比（OR）和95%置信区间（CI）。还研究了肺功能降低与OB评分的剂量依赖性关联。
男性、低收入受试者、患有合并症的个体以及肺功能降低的个体的OB评分较低（代表氧化平衡）。总体而言，氧化失衡与肺功能降低之间的关联在FVC中比在FEV中更显著（OR [95% CI]，1.06 [1.04 - 1.07] 对 1.03 [1.02 - 1.04]；两者p < 0.001）。肺功能降低水平与OB评分之间的线性关系显著（FEV和FVC中趋势p均<0.001）。
我们的研究结果表明，氧化失衡与肺功能降低有关。
