Nishi Kenta, Yoshimura Chie, Morita Kyohei, Ishikawa Ryoichi, Toyokura Erika, Nagasaki Tadao, Matsumoto Hisako, Nishizaka Yasuo
Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan.
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
World Allergy Organ J. 2023 Mar 20;16(3):100756. doi: 10.1016/j.waojou.2023.100756. eCollection 2023 Mar.
Bronchial thermoplasty (BT) is effective in some severe asthma patients; however, the specific asthma phenotypes that produce a good response to BT are not fully understood. Clinical data were retrospectively reviewed in severe asthma patients who underwent BT at a single institution in Japan. At the follow-up assessment, the Asthma Quality of Life Questionnaire (AQLQ) scores ( = 0.003), maintenance oral corticosteroid doses ( = 0.027), and exacerbation frequency ( = 0.017) were significantly improved, while prebronchodilator-forced expiratory volume in 1 second (% predicted) did not significantly change ( = 0.19). When we grouped the patients into 2 groups according to their body mass index levels, the AQLQ scores were more improved in patients with overweight/obesity than those with normal weight ( = 0.01). This study showed that patients with non-controlled severe asthma exhibiting overweight/obesity and low quality of life had potential benefits from BT.
支气管热成形术（BT）对一些重度哮喘患者有效；然而，对BT产生良好反应的特定哮喘表型尚未完全明确。对在日本一家机构接受BT的重度哮喘患者的临床资料进行了回顾性分析。在随访评估中，哮喘生活质量问卷（AQLQ）评分（P = 0.003）、维持口服糖皮质激素剂量（P = 0.027）和急性加重频率（P = 0.017）均显著改善，而支气管扩张剂使用前1秒用力呼气容积（%预计值）无显著变化（P = 0.19）。当我们根据体重指数水平将患者分为两组时，超重/肥胖患者的AQLQ评分比体重正常患者改善更明显（P = 0.01）。本研究表明，未得到控制的重度哮喘且超重/肥胖、生活质量较低的患者可能从BT中获益。
