Liu HongKun, Zheng HongYi, Zhang GengBiao, Zhuang JiaYan, Li WeiJia, Wu BiXia, Zheng WenBin
Department of Radiology, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Department of Radiology, The Second Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China.
J Magn Reson Imaging. 2023 Nov;58(5):1452-1459. doi: 10.1002/jmri.28706. Epub 2023 Mar 30.
The effect of carbon monoxide (CO) poisoning on the topology of brain functional networks is unclear, especially in children whose brains are still developing.
To investigate the topological alterations of the whole-brain functional connectome in children with CO poisoning and characterize its relationship with disease severity.
Cross-sectional and prospective study.
A total of 26 patients with CO poisoning and 26 healthy controls.
FIELD STRENGTH/SEQUENCE: A 3.0 T MRI system/echo planar imaging (EPI) and 3D brain volume imaging (BRAVO) sequences.
We used the network-based statistics (NBS) method to explore between-group differences in functional connectivity strength and a graph-theoretical-based analytic method to explore the topology of brain networks.
Student's t-test, chi-square test, NBS, Pearson correlation coefficient, and false discovery rate correction. The statistical significance threshold was set at P < 0.05.
The case group's brain functional network topology was impaired in comparison to the control group (reduced global efficiency and small-worldness, increased characteristic path length). According to node and edge analyses, the case group showed topologically damaged regions in the frontal lobe and basal ganglia, as well as neuronal circuits with weaker connections. Also, there was a significant correlation between the patients' coma time and the degree (r = -0.4564), efficiency (r = -0.4625), and characteristic path length (r = 0.4383) of the nodes in the left orbital inferior frontal gyrus. Carbon monoxide hemoglobin content (COHb) concentration and right rolandic operculum node characteristic path length (r = -0.3894) were significantly correlated. The node efficiency and node degree of the right middle frontal gyrus (r = 0.4447 and 0.4539) and right pallidum (r = 0.4136 and 0.4501) significantly correlated with the MMSE score.
The brain network topology of CO poisoned children is damaged, which is manifested by reduced network integration and may lead to a series of clinical symptoms in patients.
Stage 2.
一氧化碳（CO）中毒对脑功能网络拓扑结构的影响尚不清楚，尤其是在脑仍在发育的儿童中。
研究CO中毒儿童全脑功能连接组的拓扑改变，并表征其与疾病严重程度的关系。
横断面和前瞻性研究。
共26例CO中毒患者和26名健康对照者。
场强/序列：3.0 T MRI系统/回波平面成像（EPI）和三维脑容积成像（BRAVO）序列。
我们使用基于网络的统计学（NBS）方法探索功能连接强度的组间差异，并使用基于图论的分析方法探索脑网络的拓扑结构。
学生t检验、卡方检验、NBS、Pearson相关系数和错误发现率校正。统计显著性阈值设定为P < 0.05。
与对照组相比，病例组的脑功能网络拓扑结构受损（全局效率和小世界性质降低，特征路径长度增加）。根据节点和边分析，病例组在额叶和基底神经节显示拓扑受损区域，以及连接较弱的神经回路。此外，患者的昏迷时间与左侧眶额下回节点的程度（r = -0.4564）、效率（r = -0.4625）和特征路径长度（r = 0.4383）之间存在显著相关性。一氧化碳血红蛋白含量（COHb）浓度与右侧中央 operculum 节点特征路径长度（r = -0.3894）显著相关。右侧额中回（r = 0.4447和0.4539）和右侧苍白球（r = 0.4136和0.4501）的节点效率和节点度与MMSE评分显著相关。
CO中毒儿童的脑网络拓扑结构受损，表现为网络整合能力下降，可能导致患者出现一系列临床症状。
2级。
2期。
