Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Age Ageing. 2023 Mar 1;52(3). doi: 10.1093/ageing/afad042.
Alzheimer's disease (AD) is the most common cause of dementia and this progressive neurological disorder is associated with substantial mortality and morbidity. We aimed to report the burden of AD and other types of dementia in the Middle East and North Africa (MENA) region, by age, sex and sociodemographic index (SDI), for the period 1990-2019.
publicly accessible data on the prevalence, death and disability-adjusted life years (DALYs) because of AD, and other types of dementia, were retrieved from the global burden of disease 2019 project for all MENA countries from 1990 to 2019.
in 2019, the age-standardised point prevalence of dementia was 777.6 per 100,000 populations in MENA, which was 3.0% higher than in 1990. The age-standardised death and DALY rates of dementia were 25.5 and 387.0 per 100,000, respectively. In 2019, the highest DALY rate was observed in Afghanistan and the lowest rate was in Egypt. That same year, the age-standardised point prevalence, death and DALY rates increased with advancing age and were higher for females of all age groups. From 1990 to 2019, the DALY rate of dementia decreased with increasing SDI up to 0.4, then slightly increased up to an SDI of 0.75, followed by a decrease for the remaining SDI levels.
the point prevalence of AD and other types of dementia has increased over the past three decades, and in 2019, the corresponding regional burden was higher than the global average.
阿尔茨海默病（AD）是痴呆症最常见的病因，这种进行性神经退行性疾病与大量的死亡率和发病率有关。我们旨在报告 1990 年至 2019 年期间，中东和北非（MENA）地区 AD 和其他类型痴呆症的负担，按年龄、性别和社会人口指数（SDI）进行分类。
从全球疾病负担 2019 项目中检索了 1990 年至 2019 年期间所有 MENA 国家 AD 和其他类型痴呆症的患病率、死亡率和残疾调整生命年（DALYs）的公开可用数据。
2019 年，MENA 地区痴呆症的年龄标准化点患病率为每 10 万人 777.6 例，比 1990 年高 3.0%。痴呆症的年龄标准化死亡率和 DALY 率分别为每 10 万人 25.5 和 387.0。2019 年，阿富汗的 DALY 率最高，埃及的 DALY 率最低。同年，年龄标准化的点患病率、死亡率和 DALY 率随着年龄的增长而增加，所有年龄组的女性都更高。从 1990 年到 2019 年，痴呆症的 DALY 率随着 SDI 的增加而下降，直到 0.4，然后略有增加到 0.75，之后随着剩余 SDI 水平的下降而下降。
过去三十年来，AD 和其他类型痴呆症的点患病率有所增加，2019 年，该地区的相应负担高于全球平均水平。
