可溶性酪氨酸激酶 3 和 Axl 可能反映显微镜下多血管炎和肉芽肿性多血管炎患者的当前活动和肾脏受累情况。

Soluble Tyro-3 and Axl may reflect the current activity and renal involvement in patients with microscopic polyangiitis and granulomatosis with polyangiitis.

机构信息

Department of Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Department of Medical Science, BK21 Plus Project, Yonsei University, College of Medicine, Seoul, Republic of Korea.

出版信息

Clin Exp Rheumatol. 2023 Apr;41(4):948-955. doi: 10.55563/clinexprheumatol/6pltaf. Epub 2023 Mar 27.

DOI:10.55563/clinexprheumatol/6pltaf

PMID:36995311

Abstract

OBJECTIVES

This study investigated whether soluble Tyro-3 (sTyro-3), sAxl, and sMer could reflect the current activity in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA).

METHODS

This study retrospectively reviewed the medical records of 76 patients with MPA and GPA, and measure the serum concentrations of sTyro-3, sAxl, and sMer using the stored serum at AAV diagnosis. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)-specific indices included Birmingham vasculitis activity index (BVAS), five-factor score, the short-form 36-item health survey, and vasculitis damage index. High AAV activity was defined as the highest tertile of BVAS.

RESULTS

The median age of the 47 MPA and 29 GPA patients was 66.0 years and 43.4% were men. The serum concentrations of sTyro-3 and sAxl were significantly correlated with BVAS and the total score of renal manifestation. The serum concentrations of sTyro-3 and sAxl were independently correlated with BVAS (β=0.343 and β=0.310, respectively). In addition, the serum concentrations of sTyro-3 and sAxl were independently associated with the renal involvement of MPA and GPA (OR 1.003 and OR 1.055, respectively).

CONCLUSIONS

This study demonstrated the potential of the serum concentrations of sTyro-3 and sAxl to reflect the current activity and renal involvement in patients with MPA and GPA.

摘要

目的

本研究旨在探讨可溶性酪氨酸激酶 3（sTyro-3）、sAxl 和 sMer 是否能够反映显微镜下多血管炎（MPA）和肉芽肿性多血管炎（GPA）患者的当前活动情况。

方法

本研究回顾性分析了 76 例 MPA 和 GPA 患者的病历，并使用诊断时储存的血清测量了 sTyro-3、sAxl 和 sMer 的血清浓度。抗中性粒细胞胞质抗体（ANCA）相关性血管炎（AAV）特异性指标包括伯明翰血管炎活动指数（BVAS）、五因子评分、简化 36 项健康调查和血管炎损伤指数。高 AAV 活动定义为 BVAS 的最高三分位。

结果

47 例 MPA 和 29 例 GPA 患者的中位年龄为 66.0 岁，43.4%为男性。sTyro-3 和 sAxl 的血清浓度与 BVAS 和肾脏表现的总评分显著相关。sTyro-3 和 sAxl 的血清浓度与 BVAS 独立相关（β=0.343 和 β=0.310）。此外，sTyro-3 和 sAxl 的血清浓度与 MPA 和 GPA 的肾脏受累独立相关（OR 1.003 和 OR 1.055）。