（+）-KB343 的对映选择性全合成。
Enantioselective Total Synthesis of (+)-KB343.
机构信息
Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Bristol Myers Squibb, 10300 Campus Point Drive, San Diego, California 92121, United States.
出版信息
J Am Chem Soc. 2023 Apr 12;145(14):7753-7757. doi: 10.1021/jacs.3c01991. Epub 2023 Mar 30.
Abstract
A concise total synthesis of the complex guanidinium toxin KB343 is reported traversing through an unusual sequence of chemoselective transformations and strategic skeletal reorganization. The absolute configuration is confirmed through an enantioselective route, and the structures of all key intermediates and the natural product itself are unassailably confirmed through X-ray crystallographic analysis.
摘要
本文报道了复杂胍毒素 KB343 的简洁全合成，该全合成采用了一系列不寻常的选择性化学反应和策略性骨架重排。通过对映选择性途径确定了绝对构型，并且所有关键中间体和天然产物本身的结构都通过 X 射线晶体学分析得到了确凿的证实。
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