胍类次生代谢产物的化学与生物学。
The chemistry and biology of guanidine secondary metabolites.
机构信息
Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.
出版信息
Nat Prod Rep. 2021 Mar 1;38(3):586-667. doi: 10.1039/d0np00051e. Epub 2020 Oct 6.
Covering: 2017-2019Guanidine natural products isolated from microorganisms, marine invertebrates and terrestrial plants, amphibians and spiders, represented by non-ribosomal peptides, guanidine-bearing polyketides, alkaloids, terpenoids and shikimic acid derived, are the subject of this review. The topics include the discovery of new metabolites, total synthesis of natural guanidine compounds, biological activity and mechanism-of-action, biosynthesis and ecological functions.
综述内容涵盖了 2017-2019 年从微生物、海洋无脊椎动物和陆地植物、两栖动物和蜘蛛中分离得到的胍类天然产物，这些产物包括非核糖体肽、含胍基的聚酮化合物、生物碱、萜类化合物和莽草酸衍生的胍类化合物。综述的主题包括新代谢产物的发现、天然胍类化合物的全合成、生物活性和作用机制、生物合成和生态功能。
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