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[钠代谢紊乱]

[Dysnatremia].

作者信息

Förch Anna, Deetjen Phillip, Heller Axel R

机构信息

Klinik für Anästhesie und Operative Intensivmedizin, Medizinische Fakultät, Universität Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

出版信息

Anaesthesiologie. 2023 Apr;72(4):293-306. doi: 10.1007/s00101-023-01273-5. Epub 2023 Mar 30.

DOI:10.1007/s00101-023-01273-5
PMID:36995370
Abstract

Changes in serum sodium concentrations are frequently encountered by anesthesiologists, are complex and are often inadequately treated. Feared consequences include neurological complications, such as cerebral hemorrhage, cerebral edema and coma. Dysnatremia is always accompanied disturbances in the water balance. Accordingly, these are routinely classified based on the tonicity; however, in the daily routine and especially in the acute setting, the volume status and extracellular volume are often difficult to assess. Severe symptomatic hyponatremia with impending cerebral edema is treated by administration of hypertonic saline solution. If the rise in serum sodium is too rapid, there is a risk of central pontine myelinolysis. In a second step, the cause of the hyponatremia can be investigated and the appropriate treatment can be initiated. In the case of hypernatremia, the etiology of the disorder must be clarified before treatment. The goal is to compensate for the water deficiency by correcting the cause, specific volume therapy and, if necessary, drug support. A slow and controlled compensation must be closely monitored in order to avoid neurological complications. An algorithm has been developed that provides an overview of the dysnatremias, aids with making the diagnosis and gives recommendations for treatment measures in the clinical routine.

摘要

血清钠浓度变化在麻醉医生的工作中经常遇到,情况复杂且往往治疗不当。令人担忧的后果包括神经并发症,如脑出血、脑水肿和昏迷。钠代谢紊乱总是伴随着水平衡的紊乱。因此,通常根据张力进行分类;然而,在日常工作中,尤其是在急性情况下,容量状态和细胞外液量往往难以评估。伴有即将发生脑水肿的严重症状性低钠血症通过给予高渗盐溶液进行治疗。如果血清钠升高过快,存在发生中枢性脑桥髓鞘溶解症的风险。第二步,可以调查低钠血症的原因并开始适当的治疗。对于高钠血症,在治疗前必须明确疾病的病因。目标是通过纠正病因、进行特定的容量治疗以及必要时给予药物支持来弥补水分不足。必须密切监测缓慢且可控的纠正过程,以避免神经并发症。已经开发出一种算法,该算法概述了钠代谢紊乱,有助于进行诊断并为临床常规治疗措施提供建议。

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本文引用的文献

1
Diagnosis and Management of Hyponatremia: A Review.低钠血症的诊断与治疗:综述
JAMA. 2022 Jul 19;328(3):280-291. doi: 10.1001/jama.2022.11176.
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Diagnosis and management of hypernatraemia in children.儿童高钠血症的诊断和治疗。
Acta Paediatr. 2022 Mar;111(3):505-510. doi: 10.1111/apa.16170. Epub 2021 Nov 11.
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Med Klin Intensivmed Notfmed. 2021 Nov;116(8):672-677. doi: 10.1007/s00063-021-00873-6. Epub 2021 Oct 1.
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Safety of Peripheral Administration of 3% Hypertonic Saline in Critically Ill Patients: A Literature Review.外周输注 3%高渗盐水在危重症患者中的安全性:文献综述。
Crit Care Nurse. 2021 Feb 1;41(1):25-30. doi: 10.4037/ccn2021400.
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Association Between ICU-Acquired Hypernatremia and In-Hospital Mortality: Data From the Medical Information Mart for Intensive Care III and the Electronic ICU Collaborative Research Database.重症监护病房获得性高钠血症与住院死亡率之间的关联:来自重症监护医学信息集市III和电子重症监护协作研究数据库的数据。
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Hypertonic saline, isotonic saline, water restriction, long loops diuretics, urea or vaptans to treat hyponatremia.高渗盐水、等渗盐水、水限制、长链利尿剂、尿素或血管加压素类药物治疗低钠血症。
Expert Rev Endocrinol Metab. 2020 May;15(3):195-214. doi: 10.1080/17446651.2020.1755259. Epub 2020 May 13.
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[Hypernatremia].[高钠血症]
Med Klin Intensivmed Notfmed. 2020 Apr;115(3):263-274. doi: 10.1007/s00063-020-00667-2. Epub 2020 Mar 16.
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Adverse Consequences of Overly-Rapid Correction of Hyponatremia.过度快速纠正低钠血症的不良后果。
Front Horm Res. 2019;52:130-142. doi: 10.1159/000493243. Epub 2019 Jan 15.
10
Hypervolemic Hyponatremia in Heart Failure.心力衰竭中的高容量性低钠血症。
Front Horm Res. 2019;52:113-129. doi: 10.1159/000493242. Epub 2019 Jan 15.