Gough M J, Woodhouse L, Giles G R
Gut. 1986 Mar;27(3):249-54. doi: 10.1136/gut.27.3.249.
Gastric mucosal permeability to lithium has been measured in 20 patients with an untreated duodenal ulcer, eight patients who were asymptomatic for more than one year after truncal vagotomy and drainage, 14 patients with an endoscopically proven recurrent ulcer, and 21 patients with an unsatisfactory result from truncal vagotomy and drainage for other reasons. Lithium fluxes were lowest in the asymptomatic postoperative patients (0.149 +/- 0.028 mmol Li+/15 min), but were not significantly different to the measured fluxes in patients with a duodenal ulcer before treatment (0.160 +/- 0.020 mmol Li+/15 min) or a recurrent ulcer after truncal vagotomy and drainage (0.169 +/- 0.022 mmol Li+/15 min) (SEM). By comparison the mean lithium flux in patients who were dissatisfied with the results of their previous surgery for reasons other than a recurrent ulcer (0.234 +/- 0.019 mmol Li+/15 min) was significantly higher than that observed in patients with a duodenal ulcer (p less than 0.05), patients with a recurrent ulcer (p less than 0.05) or patients who were asymptomatic after definitive ulcer surgery (p less than 0.02). Furthermore, when the lithium fluxes observed in 11 patients whose major postoperative complaint was bile vomiting (0.243 +/- 0.027 mmol Li+/15 min) were compared with results from the remaining 52 patients included in the study (0.173 +/- 0.012 mmol Li+/15 min) fluxes were significantly higher in the 'bile vomiters' (p less than 0.05).
已对20例未经治疗的十二指肠溃疡患者、8例在迷走神经干切断术和引流术后无症状超过一年的患者、14例经内镜证实有复发性溃疡的患者以及21例因其他原因迷走神经干切断术和引流效果不佳的患者测量了胃黏膜对锂的通透性。锂通量在术后无症状患者中最低（0.149±0.028 mmol Li⁺/15分钟），但与十二指肠溃疡患者治疗前（0.160±0.020 mmol Li⁺/15分钟）或迷走神经干切断术和引流术后复发性溃疡患者（0.169±0.022 mmol Li⁺/15分钟）（标准误）的测量通量无显著差异。相比之下，因复发性溃疡以外的原因对先前手术结果不满意的患者的平均锂通量（0.234±0.019 mmol Li⁺/15分钟）显著高于十二指肠溃疡患者（p<0.05）、复发性溃疡患者（p<0.05）或溃疡根治术后无症状患者（p<0.02）。此外，将11例术后主要主诉为胆汁呕吐的患者的锂通量（0.243±0.027 mmol Li⁺/15分钟）与研究中其余52例患者的结果（0.173±0.012 mmol Li⁺/15分钟）进行比较时，“胆汁呕吐者”的通量显著更高（p<0.05）。
