Müller-Lissner S A, Sonnenberg A, Hollinger A, Schattenmann G, Siewert J R, Blum A L
Br J Surg. 1982 Jun;69(6):323-7. doi: 10.1002/bjs.1800690611.
A two-marker technique avoiding transpyloric intubation was used to measure the volume of gastric secretion, the rate of gastric emptying and the degree of postprandial duodenogastric reflux in 8 dogs, 5 without and 3 with Heineke-Mikulicz pyloroplasties. The stomach emptied after a liquid fatty meal at an overall rate of 4.9 ml/min +/- 0.2 s.e.m. in animals with a normal pylorus and 5.7 +/- 0.2 ml/min in those with pyloroplasties (P less than 0.05). Though mean fractional emptying rates were similar, the fractional emptying rate was greater in animals with pyloroplasties than in those without in the first 10 and in the last 20 minutes. The rate of duodenogastric reflux was likewise greater in animals with pyloroplasties than in those without (1.8 +/- 0.2 ml/min and 0.7 +/- 0.2 ml/min respectively, P less than 0.05). The rates of gastric secretion did not differ materially (2.2 +/- 0.3 ml/min and 2.1 +/- 0.2 ml/min), but a greater proportion of the gastric contents was emptied more than once in animals with pyloroplasties than in those without (7.7 +/- 1.5 per cent and 2.3 +/- 1.0 per cent, P less than 0.05).
采用一种避免经幽门插管的双标记技术，对8只犬（5只幽门正常，3只做了海涅克-米库利兹幽门成形术）的胃分泌量、胃排空率和餐后十二指肠-胃反流程度进行了测量。正常幽门的动物在进食液体脂肪餐后，胃排空的总体速率为4.9毫升/分钟±0.2标准误，做了幽门成形术的动物为5.7±0.2毫升/分钟（P<0.05）。虽然平均排空分数率相似，但在最初10分钟和最后20分钟，做了幽门成形术的动物的排空分数率高于未做的动物。十二指肠-胃反流率同样是做了幽门成形术的动物高于未做的动物（分别为1.8±0.2毫升/分钟和0.7±0.2毫升/分钟，P<0.05）。胃分泌率没有显著差异（分别为2.2±0.3毫升/分钟和2.1±0.2毫升/分钟），但做了幽门成形术的动物中，有更大比例的胃内容物被多次排空，高于未做的动物（分别为7.7±1.5%和2.3±1.0%，P<0.05）。
