Department of Pharmacology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Department of Neurology, Affiliated Zhongda Hospital, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210009, China.
Neurosci Bull. 2023 Sep;39(9):1426-1438. doi: 10.1007/s12264-023-01052-7. Epub 2023 Mar 30.
Major depressive disorder (MDD) is a highly heterogeneous mental disorder, and its complex etiology and unclear mechanism are great obstacles to the diagnosis and treatment of the disease. Studies have shown that abnormal functions of the visual cortex have been reported in MDD patients, and the actions of several antidepressants coincide with improvements in the structure and synaptic functions of the visual cortex. In this review, we critically evaluate current evidence showing the involvement of the malfunctioning visual cortex in the pathophysiology and therapeutic process of depression. In addition, we discuss the molecular mechanisms of visual cortex dysfunction that may underlie the pathogenesis of MDD. Although the precise roles of visual cortex abnormalities in MDD remain uncertain, this undervalued brain region may become a novel area for the treatment of depressed patients.
重度抑郁症（MDD）是一种高度异质性的精神障碍，其复杂的病因和不清楚的发病机制是疾病诊断和治疗的巨大障碍。研究表明，MDD 患者的视觉皮层功能异常，几种抗抑郁药的作用与视觉皮层结构和突触功能的改善相一致。在这篇综述中，我们批判性地评估了当前表明功能失调的视觉皮层参与抑郁症发病机制和治疗过程的证据。此外，我们还讨论了可能导致 MDD 发病机制的视觉皮层功能障碍的分子机制。尽管视觉皮层异常在 MDD 中的确切作用仍不确定，但这个被低估的脑区可能成为治疗抑郁患者的一个新领域。
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