Varma J S, Smith A N, Busuttil A
Gut. 1986 May;27(5):528-33. doi: 10.1136/gut.27.5.528.
Anorectal manometry was done in 10 men with chronic radiation proctitis and symptoms of urgency, frequency, and occasional incontinence of faeces. They were compared with 10 asymptomatic age and sex-matched controls. The maximum resting anal canal pressure and the physiological sphincter length were significantly lower (p less than 0.01) in the irradiated group. The rectosphincteric reflex was absent in one patient and showed abnormalities of recovery in four others, who had received radiotherapy. The squeeze pressure of the external sphincter was not significantly different. These results indicate that dysfunction of the internal anal sphincter may contribute to patients' anorectal symptoms after pelvic radiotherapy. Histological evidence suggests that damage to the myenteric plexus is mainly responsible. The manometric function of the external sphincter remains relatively unaffected.
对10名患有慢性放射性直肠炎且有便急、尿频和偶尔大便失禁症状的男性进行了肛肠测压。将他们与10名年龄、性别匹配的无症状对照者进行比较。照射组的最大静息肛管压力和生理性括约肌长度显著较低（p<0.01）。1例患者直肠括约肌反射消失，另有4例接受过放疗的患者出现恢复异常。外括约肌的挤压压力无显著差异。这些结果表明，盆腔放疗后患者的肛肠症状可能与内括约肌功能障碍有关。组织学证据表明，主要原因是肌间神经丛受损。外括约肌的测压功能相对未受影响。
