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巴西圣保罗州麻风分枝杆菌的遗传多样性。该州为低麻风发病率地区。

Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil.

机构信息

Instituto Lauro de Souza Lima, Bauru, SP, Brasil.

Universidade Estadual Paulista, Faculdade de Medicina, Botucatu, SP, Brasil.

出版信息

Rev Soc Bras Med Trop. 2023 Mar 27;56. doi: 10.1590/0037-8682-0612-2022. eCollection 2023.

DOI:10.1590/0037-8682-0612-2022
PMID:36995787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10042472/
Abstract

BACKGROUND

Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006.

METHODS

We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state.

RESULTS

The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity.

CONCLUSIONS

A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented.

摘要

背景

巴西是世界上麻风病病例数第二多的国家，圣保罗州自 2006 年以来已被认为是非流行地区。

方法

我们分析了来自该州不同市的 125 例临床分离株中 16 个可变数串联重复序列基因座和 3 个分枝杆菌麻风菌（M. leprae）单核苷酸多态性基因座。

结果

麻风分枝杆菌的聚类模式表明，该州的麻风病传播仍在持续，包括在低流行地区发生的家族内和家族外传播。

结论

观察到麻风分枝杆菌的显著活跃循环。因此，必须实施监测和控制措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbea/10042472/5bbc40d9368a/1678-9849-rsbmt-56-e0612-2022-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbea/10042472/b58dd25b8c24/1678-9849-rsbmt-56-e0612-2022-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbea/10042472/978f7bb34b00/1678-9849-rsbmt-56-e0612-2022-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbea/10042472/5bbc40d9368a/1678-9849-rsbmt-56-e0612-2022-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbea/10042472/b58dd25b8c24/1678-9849-rsbmt-56-e0612-2022-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbea/10042472/978f7bb34b00/1678-9849-rsbmt-56-e0612-2022-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbea/10042472/5bbc40d9368a/1678-9849-rsbmt-56-e0612-2022-gf3.jpg

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