炎症性肠病对肠道微生物群的影响。
Influence of inflammatory bowel disease on intestinal microflora.
作者信息
Keighley M R, Arabi Y, Dimock F, Burdon D W, Allan R N, Alexander-Williams J
出版信息
Gut. 1978 Dec;19(12):1099-104. doi: 10.1136/gut.19.12.1099.
Abstract
The microflora of the jejunum, ileum, and colon has been studied from operative samples in Crohn's disease (n = 30), ulcerative colitis (n = 15), and controls (n = 40). There was no significant difference in the flora of patients with ulcerative colitis compared with controls. In Crohn's disease there was a significant increase in E. coli (P less than 0.001) and B. fragilis (P less than 0.001) in the ileum and of E. coli (P less than 0.001) and lactobacilli (P less than 0.01) in the colon. The abnormal ileal flora in Crohn's disease was unrelated to serological evidence of disease activity (indices: ESR, serum albumin, serum seromucoids), diameter of the ileum, or excision of the ileocaecal valve. The abnormal colonic flora in Crohn's disease was not related to presence of macroscopic colitis.
摘要
对克罗恩病（n = 30）、溃疡性结肠炎（n = 15）患者及对照组（n = 40）的空肠、回肠和结肠微生物群进行了手术样本研究。与对照组相比，溃疡性结肠炎患者的菌群无显著差异。在克罗恩病中，回肠的大肠杆菌（P < 0.001）和脆弱拟杆菌（P < 0.001）以及结肠的大肠杆菌（P < 0.001）和乳酸杆菌（P < 0.01）显著增加。克罗恩病中异常的回肠菌群与疾病活动的血清学证据（指标：血沉、血清白蛋白、血清类粘蛋白）、回肠直径或回盲瓣切除无关。克罗恩病中异常的结肠菌群与肉眼可见的结肠炎的存在无关。
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