The Ohio State University, College of Optometry, 338 W 10th Ave., Columbus, Ohio. Dr. Wells-Gray is now with the Lumata Health, 1111 N. Lee Ave., Suite 210, Oklahoma City; and.
The Ohio State University, Department of Ophthalmology and Visual Science, Havener Eye Institute, 915 Olentangy River Road, Columbus, Ohio.
Retin Cases Brief Rep. 2024 Jul 1;18(4):507-511. doi: 10.1097/ICB.0000000000001423.
The purpose of this study was to investigate the outer retinal changes in a patient with type 2 acute macular neuroretinopathy (AMN).
A 35-year-old White woman complaining of a unilateral blind spot was imaged using various retinal imaging modalities including clinical optical coherence tomography (OCT), OCT-angiography, fundus fluorescein angiography, and adaptive optics (AO).
Fundus examination revealed multiple paracentral reddish brown petaloid lesions in the symptomatic left eye, while the other eye was unremarkable. Clinical OCT showed areas of hyperreflectance at the outer plexiform layer/outer nuclear layer complex with a disrupted inner/outer segment junction, which are characteristic features of type 2 AMN. AO imaging further revealed either shortening or absence of cone outer segments within the AMN lesions attributing to the darker features observed in the en face images from fundus photography and scanning laser ophthalmoscopy.
The AO findings indicate that the petaloid lesions in type 2 AMN are caused by a combination of the shortening and absence of the outer segment in individual cone photoreceptors.
本研究旨在探讨 2 型急性黄斑神经视网膜病变（AMN）患者的视网膜外层变化。
对一名 35 岁白人女性进行了各种视网膜成像方式的检查，包括临床光学相干断层扫描（OCT）、OCT 血管造影、眼底荧光血管造影和自适应光学（AO）。
眼底检查显示左眼症状性多发性旁中心红棕色花瓣状病变，而右眼无明显异常。临床 OCT 显示外丛状层/外核层复合体的高反射区，伴有内/外节连接中断，这是 2 型 AMN 的特征性表现。AO 成像进一步显示 AMN 病变内的锥体外节缩短或缺失，这归因于眼底照相和扫描激光检眼镜的共焦图像中观察到的较暗特征。
AO 结果表明，2 型 AMN 的花瓣状病变是由单个视锥光感受器的外节缩短和缺失共同引起的。
