Department of Ophthalmology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy; and.
Università Vita-Salute San Raffaele, Milan, Italy.
Retina. 2023 Aug 1;43(8):1348-1355. doi: 10.1097/IAE.0000000000003801.
To describe a sign that takes the form of a continuous hyperreflective band within the thickness of the ganglion cell layer (GCL), thus dubbed the "hyperreflective ganglion cell layer band" (HGB), which the authors detected in a fraction of patients affected by retinitis pigmentosa (RP).
Retrospective, cross-sectional, observational study. Optical coherence tomography (OCT) images of patients with RP examined between May 2015 and June 2021 were retrospectively reviewed for the presence of HGB, epiretinal membrane (ERM), macular hole, and cystoid macular edema (CME). The ellipsoid zone (EZ) width was also measured. A subgroup of patients underwent microperimetry in the central 2°, 4°, and 10°.
One hundred and fifty-four eyes from 77 subjects were included in the study. The HGB was present in 39 (25.3%) eyes with RP. Mean best-corrected visual acuity (BCVA) was 0.39 ± 0.05 logMAR (approximately 20/50 Snellen equivalent) and 0.18 ± 0.03 logMAR (approximately 20/32 Snellen equivalent) in eyes with and without HGB, respectively ( P < 0.001). The two groups did not differ regarding EZ width; mean 2°, 4°, and 10° retinal sensitivity; and prevalence of CME, ERM, and macular hole. The multivariable analysis showed the presence of HGB to be a predictor of poorer BCVA ( P < 0.001).
HGB is an OCT finding detectable in approximately a quarter of eyes with RP and is associated with a poorer visual function. In the discussion, the authors speculate about possible morphogenetic scenarios to explain this observation.
描述一种在神经节细胞层（GCL）厚度内呈现连续高反射带的征象，因此将其命名为“高反射神经节细胞层带”（HGB），作者在一部分患有色素性视网膜炎（RP）的患者中发现了这种征象。
回顾性、横断面、观察性研究。回顾性分析 2015 年 5 月至 2021 年 6 月期间检查的 RP 患者的光学相干断层扫描（OCT）图像，观察是否存在 HGB、视网膜前膜（ERM）、黄斑裂孔和囊样黄斑水肿（CME）。还测量了椭圆体带（EZ）的宽度。一部分患者在中央 2°、4°和 10°进行微视野检查。
本研究纳入了 77 例患者的 154 只眼。39 只（25.3%）RP 眼存在 HGB。HGB 眼的最佳矫正视力（BCVA）平均值为 0.39±0.05 logMAR（约 20/50 斯耐伦等效），无 HGB 眼的 BCVA 平均值为 0.18±0.03 logMAR（约 20/32 斯耐伦等效）（P<0.001）。两组间 EZ 宽度、2°、4°和 10°视网膜敏感性以及 CME、ERM 和黄斑裂孔的发生率均无差异。多变量分析显示 HGB 的存在是 BCVA 较差的预测因素（P<0.001）。
HGB 是一种在大约四分之一的 RP 眼中可检测到的 OCT 发现，与较差的视力功能相关。在讨论中，作者推测了可能的形态发生情景来解释这一观察结果。
