van Dijk Albert, Guabiraba Rodrigo, Bailleul Geoffrey, Schouler Catherine, Haagsman Henk P, Lalmanach Anne-Christine
Department Biomolecular Health Sciences, Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
INRAE, Université de Tours, ISP, F-37380, Nouzilly, France.
Mol Immunol. 2023 May;157:53-69. doi: 10.1016/j.molimm.2023.03.011. Epub 2023 Mar 28.
Divergent evolution for more than 310 million years has resulted in an avian immune system that is complex and more compact than that of primates, sharing much of its structure and functions. Not surprisingly, well conserved ancient host defense molecules, such as defensins and cathelicidins, have diversified over time. In this review, we describe how evolution influenced the host defense peptides repertoire, its distribution, and the relationship between structure and biological functions. Marked features of primate and avian HDPs are linked to species-specific characteristics, biological requirements, and environmental challenge.
超过3.1亿年的趋异进化造就了一种禽类免疫系统，它比灵长类动物的免疫系统更为复杂且紧凑，在结构和功能上有许多共同之处。不足为奇的是，诸如防御素和杀菌肽等保守的古老宿主防御分子随着时间的推移已经多样化。在本综述中，我们描述了进化如何影响宿主防御肽库、其分布以及结构与生物学功能之间的关系。灵长类和禽类宿主防御肽的显著特征与物种特异性特征、生物学需求及环境挑战相关联。
