Department of Ophthalmology, Children's Hospital of Nanjing Medical University, Nanjing, China,
Department of Ophthalmology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Ophthalmic Res. 2023;66(1):801-808. doi: 10.1159/000530059. Epub 2023 Mar 30.
Intermittent exotropia is the most prevalent subtype of exotropia in children. Part-time occlusion (PTO) as an anti-suppression therapy was applied for nonsurgical management of intermittent exotropia.
The aim of the study was to compare the effectiveness of PTO therapy and observation in the treatment of intermittent exotropia.
An exhaustive search of the literature from PubMed, Embase, Web of Science, and Cochrane Library databases was carried out until July 2022. No language restrictions were applied. The literature was rigorously screened against eligibility criteria. Weighted mean differences and 95% confidence interval (CI) were calculated.
A total of 4 articles with 617 participants were included in this meta-analysis. Our pooled results showed that PTO exhibited superior effects compared to observation, with greater decrease in exotropia control at distance and near (MD = -0.38, 95% CI: -0.57 to -0.20, p < 0.001; MD = -0.36, 95% CI: -0.54 to -0.18, p < 0.001); patients subjected to PTO therapy had greater decrease in distance deviations (MD = -1.95, 95% CI: -3.13 to -0.76, p = 0.001), and there was greater improvement in near stereoacuity among the PTO group in comparison with the observation group (p < 0.001).
The present meta-analysis indicated that PTO therapy showed a better effect in improving control and near stereopsis and decreasing distance exodeviation angle of children with intermittent exotropia in comparison with observation.
间歇性外斜视是儿童中最常见的外斜视亚型。部分时间遮盖（PTO）作为一种抗抑制治疗方法，被应用于间歇性外斜视的非手术治疗。
本研究旨在比较 PTO 治疗与观察在间歇性外斜视治疗中的效果。
从 PubMed、Embase、Web of Science 和 Cochrane Library 数据库中进行全面的文献检索，检索时间截至 2022 年 7 月，不限制语言。根据纳入和排除标准严格筛选文献。计算加权均数差和 95%置信区间（CI）。
本荟萃分析共纳入 4 篇文章，共计 617 名参与者。我们的汇总结果表明，与观察相比，PTO 具有更好的效果，在远距和近距时斜视控制的改善更明显（MD=-0.38，95%CI：-0.57 至-0.20，p < 0.001；MD=-0.36，95%CI：-0.54 至-0.18，p < 0.001）；接受 PTO 治疗的患者在远距偏斜度方面的改善更大（MD=-1.95，95%CI：-3.13 至-0.76，p=0.001），并且 PTO 组在近立体视锐度方面的改善明显优于观察组（p < 0.001）。
本荟萃分析表明，与观察相比，PTO 治疗在改善间歇性外斜视儿童的控制和近立体视以及减少远距外斜视角度方面效果更好。
