Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Department of Pharmacy, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Epidemiol Health. 2023;45:e2023038. doi: 10.4178/epih.e2023038. Epub 2023 Mar 21.
The aim of this study was to evaluate the disease burden of prostate cancer (PC) and assess key influencing factors associated with the disease expenditures of PC in the United States.
The total deaths, incidence, prevalence, and disability-adjusted life-years of PC were obtained from the Global Burden of Disease Study 2019. The Medical Expenditure Panel Survey was used to estimate healthcare expenditures and productivity loss and to investigate patterns of payment and use of healthcare resources in the United States. A multivariable logistic regression model was conducted to identify key factors influencing expenditures.
For patients aged 50 and older, the burden for all age groups showed a modest increase over the 6-year period. Annual medical expenditures were estimated to range from US$24.8 billion to US$39.2 billion from 2014 to 2019. The annual loss in productivity for patients was approximately US$1,200. The top 3 major components of medical costs were hospital inpatient stays, prescription medicines, and office-based visits. Medicare was the largest source of payments for survivors. In terms of drug consumption, genitourinary tract agents (57.0%) and antineoplastics (18.6%) were the main therapeutic drugs. High medical expenditures were positively associated with age (p=0.005), having private health insurance (p=0.016), more comorbidities, not currently smoking (p=0.001), and patient self-perception of fair/poor health status (p<0.001).
From 2014 to 2019, the national real-world data of PC revealed that the disease burden in the United States continued to increase, which was partly related to patient characteristics.
本研究旨在评估前列腺癌（PC）的疾病负担，并评估与美国 PC 疾病支出相关的关键影响因素。
从 2019 年全球疾病负担研究中获得 PC 的总死亡人数、发病率、患病率和伤残调整生命年。使用医疗支出面板调查来估计医疗保健支出和生产力损失，并调查美国的支付模式和医疗资源的使用情况。采用多变量逻辑回归模型确定影响支出的关键因素。
对于 50 岁及以上的患者，所有年龄组的负担在 6 年内呈适度增长。估计 2014 年至 2019 年期间，每年的医疗支出范围在 248 亿至 392 亿美元之间。患者每年的生产力损失约为 1200 美元。医疗费用的前三大组成部分是住院病人住院、处方药物和门诊就诊。对于幸存者来说，医疗保险是最大的支付来源。在药物消耗方面，泌尿系统药物（57.0%）和抗肿瘤药物（18.6%）是主要的治疗药物。高医疗支出与年龄（p=0.005）、拥有私人医疗保险（p=0.016）、更多的合并症、不吸烟（p=0.001）和患者自我感知的健康状况不佳（p<0.001）呈正相关。
从 2014 年到 2019 年，美国 PC 的真实世界数据表明，美国的疾病负担持续增加，这在一定程度上与患者特征有关。
