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2020/2021年重要更新：推进直肠癌综合治疗的精准医学

Essential updates 2020/2021: Advancing precision medicine for comprehensive rectal cancer treatment.

作者信息

Takemasa Ichiro, Hamabe Atsushi, Miyo Masaaki, Akizuki Emi, Okuya Koichi

机构信息

Department of Surgery, Surgical Oncology and Science Sapporo Medical University Sapporo Japan.

Department of Gastroenterological Surgery, Graduate School of Medicine Osaka University Osaka Japan.

出版信息

Ann Gastroenterol Surg. 2022 Dec 27;7(2):198-215. doi: 10.1002/ags3.12646. eCollection 2023 Mar.

DOI:10.1002/ags3.12646
PMID:36998300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10043777/
Abstract

In the paradigm shift related to rectal cancer treatment, we have to understand a variety of new emerging topics to provide appropriate treatment for individual patients as precision medicine. However, information on surgery, genomic medicine, and pharmacotherapy is highly specialized and subdivided, creating a barrier to achieving thorough knowledge. In this review, we summarize the perspective for rectal cancer treatment and management from the current standard-of-care to the latest findings to help optimize treatment strategy.

摘要

在与直肠癌治疗相关的范式转变中，我们必须了解各种新出现的主题，以便作为精准医学为个体患者提供适当的治疗。然而，关于手术、基因组医学和药物治疗的信息高度专业化且细分，这为全面掌握知识造成了障碍。在这篇综述中，我们总结了从当前的标准治疗到最新研究结果的直肠癌治疗和管理观点，以帮助优化治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d1b/10043777/d86078b10768/AGS3-7-198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d1b/10043777/64812c45d25a/AGS3-7-198-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d1b/10043777/31d922dd6756/AGS3-7-198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d1b/10043777/e48c0e74fbb4/AGS3-7-198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d1b/10043777/d86078b10768/AGS3-7-198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d1b/10043777/64812c45d25a/AGS3-7-198-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d1b/10043777/31d922dd6756/AGS3-7-198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d1b/10043777/e48c0e74fbb4/AGS3-7-198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d1b/10043777/d86078b10768/AGS3-7-198-g001.jpg

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Ann Gastroenterol Surg. 2022 Jul 3;6(6):767-777. doi: 10.1002/ags3.12592. eCollection 2022 Nov.
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Artificial intelligence-based technology to make a three-dimensional pelvic model for preoperative simulation of rectal cancer surgery using MRI.基于人工智能的技术，利用磁共振成像（MRI）制作直肠癌手术术前模拟的三维骨盆模型。
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Sci Rep. 2025 Mar 14;15(1):8903. doi: 10.1038/s41598-025-93349-y.
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Upfront surgery, neoadjuvant chemoradiotherapy, or neoadjuvant chemotherapy for rectal cancer with lateral lymph node metastasis: A multicenter MRI and lateral lymph node dissection study.upfront手术、新辅助放化疗或新辅助化疗用于治疗伴有侧方淋巴结转移的直肠癌：一项多中心MRI及侧方淋巴结清扫研究。
Ann Gastroenterol Surg. 2024 Oct 16;9(2):309-318. doi: 10.1002/ags3.12873. eCollection 2025 Mar.
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