接受治疗的人类免疫缺陷病毒感染者的冠状动脉斑块成分和严重程度与炎性小体有关。
Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus.
作者信息
Schnittman Samuel R, Kitch Douglas W, Swartz Talia H, Burdo Tricia H, Fitch Kathleen V, McCallum Sara, Flynn Jacqueline M, Fulda Evelynne S, Diggs Marissa R, Stapleton Jack T, Casado José L, Taron Jana, Currier Judith S, Zanni Markella V, Malvestutto Carlos, Fichtenbaum Carl J, Aberg Judith A, Ribaudo Heather J, Lu Michael T, Douglas Pamela S, Grinspoon Steven K
机构信息
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Metabolism Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
出版信息
Open Forum Infect Dis. 2023 Mar 1;10(3):ofad106. doi: 10.1093/ofid/ofad106. eCollection 2023 Mar.
Abstract
BACKGROUND
Inflammasome activation is increased in people with human immunodeficiency virus (PWH), but its relationship with coronary plaque is poorly understood in this setting.
METHODS
In a large human immunodeficiency virus cardiovascular prevention cohort, relationships between caspase-1, interleukin (IL)-1β, and IL-18 and coronary plaque indices were assessed by multivariate logistic regression.
RESULTS
Higher IL-18 and IL-1β were associated with Leaman score, an integrative measure of plaque burden and composition.
CONCLUSIONS
As Leaman score >5 is associated with cardiovascular events in the general population, future work is needed to determine how the inflammasome relates to events and whether strategies to reduce its activation affect events or plaque progression among PWH.
摘要
背景
人类免疫缺陷病毒感染者（PWH）体内炎性小体激活增加，但在这种情况下其与冠状动脉斑块的关系尚不清楚。
方法
在一个大型人类免疫缺陷病毒心血管预防队列中，通过多变量逻辑回归评估半胱天冬酶-1、白细胞介素（IL）-1β和IL-18与冠状动脉斑块指数之间的关系。
结果
较高的IL-18和IL-1β与利曼评分相关，利曼评分是斑块负荷和成分的综合指标。
结论
由于在一般人群中利曼评分>5与心血管事件相关，未来需要开展研究以确定炎性小体与事件之间的关系，以及降低其激活的策略是否会影响PWH的心血管事件或斑块进展。
相似文献
1
Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus.接受治疗的人类免疫缺陷病毒感染者的冠状动脉斑块成分和严重程度与炎性小体有关。
Open Forum Infect Dis. 2023 Mar 1;10(3):ofad106. doi: 10.1093/ofid/ofad106. eCollection 2023 Mar.
2
Assessment of Coronary Artery Disease With Computed Tomography Angiography and Inflammatory and Immune Activation Biomarkers Among Adults With HIV Eligible for Primary Cardiovascular Prevention.在适合进行一级心血管预防的 HIV 成年患者中，使用计算机断层扫描血管造影术和炎症及免疫激活生物标志物评估冠心病。
JAMA Netw Open. 2021 Jun 1;4(6):e2114923. doi: 10.1001/jamanetworkopen.2021.14923.
3
Pericoronary Adipose Tissue Density, Inflammation, and Subclinical Coronary Artery Disease Among People With HIV in the REPRIEVE Cohort.在 REPRIEVE 队列中，HIV 感染者的冠状动脉旁脂肪组织密度、炎症与亚临床冠状动脉疾病。
Clin Infect Dis. 2023 Dec 15;77(12):1676-1686. doi: 10.1093/cid/ciad419.
4
Association of Cardiac Troponin T With Coronary Atherosclerosis in Asymptomatic Primary Prevention People With HIV.无症状HIV初治人群中心肌肌钙蛋白T与冠状动脉粥样硬化的关联
JACC Adv. 2024 Aug 16;3(9):101206. doi: 10.1016/j.jacadv.2024.101206. eCollection 2024 Sep.
5
The Association between IL-1β and IL-18 Levels, Gut Barrier Disruption, and Monocyte Activation during Chronic Simian Immunodeficiency Virus Infection and Long-Term Suppressive Antiretroviral Therapy.在慢性猴免疫缺陷病毒感染和长期抑制性抗逆转录病毒治疗期间，IL-1β 和 IL-18 水平、肠道屏障破坏和单核细胞活化之间的关联。
Int J Mol Sci. 2024 Aug 9;25(16):8702. doi: 10.3390/ijms25168702.
6
Comparison of Two Modern Survival Prediction Tools, SORG-MLA and METSSS, in Patients With Symptomatic Long-bone Metastases Who Underwent Local Treatment With Surgery Followed by Radiotherapy and With Radiotherapy Alone.两种现代生存预测工具 SORG-MLA 和 METSSS 在接受手术联合放疗和单纯放疗治疗有症状长骨转移患者中的比较。
Clin Orthop Relat Res. 2024 Dec 1;482(12):2193-2208. doi: 10.1097/CORR.0000000000003185. Epub 2024 Jul 23.
7
Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers in HIV: Mechanistic Substudy of the REPRIEVE Randomized Clinical Trial.吡咯烷二硫代氨基甲酸盐对 HIV 患者冠心病及炎症生物标志物的影响：REPRIEVE 随机临床试验的机制亚研究。
JAMA Cardiol. 2024 Apr 1;9(4):323-334. doi: 10.1001/jamacardio.2023.5661.
8
Sex Differences in Subclinical Atherosclerosis and Systemic Immune Activation/Inflammation Among People With Human Immunodeficiency Virus in the United States.美国人类免疫缺陷病毒感染者亚临床动脉粥样硬化和全身免疫激活/炎症的性别差异。
Clin Infect Dis. 2023 Jan 13;76(2):323-334. doi: 10.1093/cid/ciac767.
9
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.慢性斑块状银屑病的全身药理学治疗：一项网状荟萃分析。
Cochrane Database Syst Rev. 2017 Dec 22;12(12):CD011535. doi: 10.1002/14651858.CD011535.pub2.
10
Genetically predicted lipoprotein(a) associates with coronary artery plaque severity independent of low-density lipoprotein cholesterol.基因预测的脂蛋白(a)与冠状动脉斑块严重程度相关，独立于低密度脂蛋白胆固醇。
Eur J Prev Cardiol. 2025 Jan 27;32(2):116-127. doi: 10.1093/eurjpc/zwae271.
引用本文的文献
1
The association between systemic inflammation and albuminuria among people living with HIV: A cross-sectional study from Botswana.博茨瓦纳艾滋病毒感染者全身炎症与蛋白尿之间的关联：一项横断面研究
Medicine (Baltimore). 2025 Aug 8;104(32):e43772. doi: 10.1097/MD.0000000000043772.
2
Targeting inflammasomes as a therapeutic potential for HIV/AIDS.将炎性小体作为治疗HIV/AIDS的潜在靶点。
Cell Mol Life Sci. 2025 Apr 17;82(1):162. doi: 10.1007/s00018-025-05685-x.
3
Galectin-3, Galectin-9, and Interleukin-18 Are Associated with Monocyte/Macrophage Activation and Turnover More so than Simian Immunodeficiency Virus-Associated Cardiac Pathology or Encephalitis.半乳糖凝集素-3、半乳糖凝集素-9 和白细胞介素-18 与单核细胞/巨噬细胞的活化和更替的相关性大于猴免疫缺陷病毒相关性心脏病理或脑炎。
AIDS Res Hum Retroviruses. 2024 Sep;40(9):531-542. doi: 10.1089/AID.2024.0008. Epub 2024 Jun 12.
4
HIV Infection Drives Foam Cell Formation via NLRP3 Inflammasome Activation.HIV 感染通过 NLRP3 炎性小体激活驱动泡沫细胞形成。
Int J Mol Sci. 2024 Feb 17;25(4):2367. doi: 10.3390/ijms25042367.
本文引用的文献
1
Increased Macrophage-Specific Arterial Infiltration Relates to Noncalcified Plaque and Systemic Immune Activation in People With Human Immunodeficiency Virus.巨噬细胞特异性动脉浸润增加与人类免疫缺陷病毒感染者的非钙化斑块和全身免疫激活有关。
J Infect Dis. 2022 Nov 11;226(10):1823-1833. doi: 10.1093/infdis/jiac301.
2
Assessment of Coronary Artery Disease With Computed Tomography Angiography and Inflammatory and Immune Activation Biomarkers Among Adults With HIV Eligible for Primary Cardiovascular Prevention.在适合进行一级心血管预防的 HIV 成年患者中，使用计算机断层扫描血管造影术和炎症及免疫激活生物标志物评估冠心病。
JAMA Netw Open. 2021 Jun 1;4(6):e2114923. doi: 10.1001/jamanetworkopen.2021.14923.
3
Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1β inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis.在用卡那单抗成功抑制白细胞介素-1β后，白细胞介素-18和白细胞介素-6相关的残余炎症风险：开发靶向抗细胞因子疗法治疗动脉粥样硬化血栓形成的进一步理论依据。
Eur Heart J. 2020 Jun 14;41(23):2153-2163. doi: 10.1093/eurheartj/ehz542.
4
Caspase-1 Activation Is Related With HIV-Associated Atherosclerosis in an HIV Transgenic Mouse Model and HIV Patient Cohort.半胱氨酸天冬氨酸蛋白酶-1 的激活与 HIV 相关动脉粥样硬化有关，在 HIV 转基因小鼠模型和 HIV 患者队列中得到证实。
Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1762-1775. doi: 10.1161/ATVBAHA.119.312603. Epub 2019 Jul 18.
5
Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals.白细胞介素 1 激活的可溶性标志物可预测 HIV 感染者首次心肌梗死。
J Infect Dis. 2020 Feb 3;221(4):506-509. doi: 10.1093/infdis/jiz253.
6
Rationale and design of the Mechanistic Substudy of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE): Effects of pitavastatin on coronary artery disease and inflammatory biomarkers.随机试验预防 HIV 血管事件的机制亚研究的原理和设计 (REPRIEVE)：匹伐他汀对冠心病和炎症生物标志物的影响。
Am Heart J. 2019 Jun;212:1-12. doi: 10.1016/j.ahj.2019.02.011. Epub 2019 Mar 4.
7
IL-1β Inhibition Reduces Atherosclerotic Inflammation in HIV Infection.白细胞介素-1β抑制可减轻HIV感染中的动脉粥样硬化炎症。
J Am Coll Cardiol. 2018 Dec 4;72(22):2809-2811. doi: 10.1016/j.jacc.2018.09.038.
8
Increased Systemic Inflammation and Gut Permeability Among Women With Treated HIV Infection in Rural Uganda.在乌干达农村地区，接受治疗的 HIV 感染女性中，全身性炎症和肠道通透性增加。
J Infect Dis. 2018 Aug 14;218(6):922-926. doi: 10.1093/infdis/jiy244.
9
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.卡那奴单抗治疗动脉粥样硬化疾病的抗炎疗法。
N Engl J Med. 2017 Sep 21;377(12):1119-1131. doi: 10.1056/NEJMoa1707914. Epub 2017 Aug 27.
10
Long-term prognostic impact of CT-Leaman score in patients with non-obstructive CAD: Results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) study.CT-利曼评分对非阻塞性冠心病患者的长期预后影响：国际多中心临床结果冠状动脉CT血管造影评估（CONFIRM）研究的结果
Int J Cardiol. 2017 Mar 15;231:18-25. doi: 10.1016/j.ijcard.2016.12.137. Epub 2016 Dec 28.
Zotero 插件