Bai Xin-Yue, Liu Xiao-Long, Deng Zhi-Zhong, Wei Dong-Min, Zhang Die, Xi Hui-Lin, Wang Qing-Yan, He Meng-Ze, Yang Yan-Ling
School of Medicine, Yan'an University, Yan'an, China.
Front Neurosci. 2023 Mar 14;17:1136143. doi: 10.3389/fnins.2023.1136143. eCollection 2023.
Spinal cord injury is a serious traumatic disease. As Ferroptosis has been increasingly studied in recent years, it has been found to be closely related to the pathophysiological processes of spinal cord injury. Iron overload, reactive oxygen species accumulation, lipid peroxidation and glutamate accumulation associated with Ferroptosis are all present in spinal cord injury, and thus Ferroptosis is thought to be involved in the pathological processes secondary to spinal cord injury. This article highlights the relationship between Ferroptosis and spinal cord injury, lists substances that improve spinal cord injury by inhibiting Ferroptosis, and concludes with a discussion of the problems that may be encountered in the clinical translation of Ferroptosis inhibitors as a means of enabling their faster use in clinical treatment.
脊髓损伤是一种严重的创伤性疾病。近年来，随着铁死亡的研究日益增多，发现它与脊髓损伤的病理生理过程密切相关。与铁死亡相关的铁过载、活性氧积累、脂质过氧化和谷氨酸积累在脊髓损伤中均有出现，因此认为铁死亡参与了脊髓损伤继发的病理过程。本文重点阐述了铁死亡与脊髓损伤之间的关系，列举了通过抑制铁死亡改善脊髓损伤的物质，并讨论了铁死亡抑制剂临床转化过程中可能遇到的问题，以期其能更快应用于临床治疗。
