Pai Emily Ling-Lin, Stafford April M, Vogt Daniel
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, United States.
Department of Pediatrics and Human Development, Michigan State University, Grand Rapids, MI, United States.
Front Neurosci. 2023 Mar 14;17:1138653. doi: 10.3389/fnins.2023.1138653. eCollection 2023.
The development and maturation of cortical GABAergic interneurons has been extensively studied, with much focus on nuclear regulation transcription factors. While these seminal events are critical for the establishment of interneuron developmental milestones, recent studies on cellular signaling cascades have begun to elucidate some potential contributions of cell signaling during development. Here, we review studies underlying three broad signaling families, mTOR, MAPK, and Wnt/beta-catenin in cortical interneuron development. Notably, each pathway harbors signaling factors that regulate a breadth of interneuron developmental milestones and properties. Together, these events may work in conjunction with transcriptional mechanisms and other events to direct the complex diversity that emerges during cortical interneuron development and maturation.
皮质GABA能中间神经元的发育和成熟已得到广泛研究，其中很多研究聚焦于核调节转录因子。虽然这些重要事件对于中间神经元发育里程碑的建立至关重要，但最近关于细胞信号级联反应的研究已开始阐明发育过程中细胞信号的一些潜在作用。在此，我们综述了在皮质中间神经元发育中涉及的三个主要信号家族，即mTOR、MAPK和Wnt/β-连环蛋白的相关研究。值得注意的是，每条信号通路都含有调节多种中间神经元发育里程碑和特性的信号因子。这些事件共同作用，可能与转录机制及其他事件协同，引导皮质中间神经元发育和成熟过程中出现的复杂多样性。
