Sekulovski Metodija, Bogdanova-Petrova Simona, Peshevska-Sekulovska Monika, Velikova Tsvetelina, Georgiev Tsvetoslav
Department of Anesthesiology and Intensive Care, University Hospital Lozenetz, Sofia 1407, Bulgaria.
Medical Faculty, Sofia University St. Kliment Ohridski, Sofia 1407, Bulgaria.
World J Clin Cases. 2023 Mar 26;11(9):1918-1929. doi: 10.12998/wjcc.v11.i9.1918.
While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly spread across the globe, our understanding of its pathogenic mechanisms evolved. Importantly, coronavirus disease 2019 (COVID-19) is now considered a syndromic multisystem inflammatory disease involving not only the respiratory system but also the cardiovascular, excretory, nervous, musculoskeletal, and gastrointestinal systems. Moreover, a membrane-bound form of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2, is expressed on the surface of cholangiocytes and hepatocytes, suggesting the potential of COVID-19 to involve the liver. With the widespread distribution of SARS-CoV-2 throughout the population, infection during pregnancy is no longer a rare occurrence; however, little is known about the course of hepatic injuries and related outcomes in pregnant SARS-CoV-2-positive women. Thus, the understudied topic of COVID-related liver disease during pregnancy poses a great challenge for the consulting gynecologist and hepatologist. In this review, we aim to describe and summarize potential liver injuries in pregnant women with COVID-19.
虽然严重急性呼吸综合征冠状病毒2（SARS-CoV-2）迅速在全球传播，但我们对其致病机制的认识不断演变。重要的是，2019冠状病毒病（COVID-19）现在被认为是一种综合征性多系统炎症性疾病，不仅累及呼吸系统，还累及心血管、排泄、神经、肌肉骨骼和胃肠道系统。此外，SARS-CoV-2的进入受体血管紧张素转换酶2的膜结合形式在胆管细胞和肝细胞表面表达，提示COVID-19累及肝脏的可能性。随着SARS-CoV-2在人群中的广泛传播，孕期感染已不再罕见；然而，对于SARS-CoV-2阳性孕妇的肝损伤过程及相关结局知之甚少。因此，孕期COVID相关肝病这一研究不足的话题给咨询妇科医生和肝病学家带来了巨大挑战。在这篇综述中，我们旨在描述和总结COVID-19孕妇潜在的肝损伤。
