Department of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Front Immunol. 2023 Mar 14;14:1103592. doi: 10.3389/fimmu.2023.1103592. eCollection 2023.
Atherosclerosis (AS) is a chronic inflammatory disease, involving a pathological process of endothelial dysfunction, lipid deposition, plaque rupture, and arterial occlusion, and is one of the leading causes of death in the world population. The progression of AS is closely associated with several inflammatory diseases, among which periodontitis has been shown to increase the risk of AS. (), presenting in large numbers in subgingival plaque biofilms, is the "dominant flora" in periodontitis, and its multiple virulence factors are important in stimulating host immunity. Therefore, it is significant to elucidate the potential mechanism and association between and AS to prevent and treat AS. By summarizing the existing studies, we found that promotes the progression of AS through multiple immune pathways. can escape host immune clearance and, in various forms, circulate with blood and lymph and colonize arterial vessel walls, directly inducing local inflammation in blood vessels. It also induces the production of systemic inflammatory mediators and autoimmune antibodies, disrupts the serum lipid profile, and thus promotes the progression of AS. In this paper, we summarize the recent evidence (including clinical studies and animal studies) on the correlation between and AS, and describe the specific immune mechanisms by which promotes AS progression from three aspects (immune escape, blood circulation, and lymphatic circulation), providing new insights into the prevention and treatment of AS by suppressing periodontal pathogenic bacteria.
动脉粥样硬化（AS）是一种慢性炎症性疾病，涉及内皮功能障碍、脂质沉积、斑块破裂和动脉阻塞的病理过程，是世界人口死亡的主要原因之一。AS 的进展与几种炎症性疾病密切相关，其中牙周炎已被证明会增加 AS 的风险。牙龈卟啉单胞菌（）大量存在于龈下菌斑生物膜中，是牙周炎的“优势菌群”，其多种毒力因子在刺激宿主免疫方面起着重要作用。因此，阐明和 AS 之间的潜在机制和关联对于预防和治疗 AS 具有重要意义。通过总结现有研究，我们发现通过多种免疫途径促进 AS 的进展。可以逃避宿主免疫清除，以多种形式随血液和淋巴循环，并定植于动脉血管壁，直接在血管内引起局部炎症。它还诱导产生全身炎症介质和自身抗体，破坏血清脂质谱，从而促进 AS 的进展。本文总结了近年来关于与 AS 相关的最新证据（包括临床研究和动物研究），并从免疫逃避、血液循环和淋巴循环三个方面描述了促进 AS 进展的具体免疫机制，为通过抑制牙周致病菌预防和治疗 AS 提供了新的思路。
