Meeralam Yaser, Al Qurashi Bushra, Al Masoudi Assel, Alhejaili Talal L, Khayat Mohammed, Aljoaid Anas M, Al Harthi Wallaa, Hafiz Waleed A, Shariff Mohammed K
Digestive and Liver Health Center, King Abdullah Medical City, Makkah, SAU.
Internal Medicine Department, King Abdullah Medical City, Makkah, SAU.
Cureus. 2023 Feb 25;15(2):e35473. doi: 10.7759/cureus.35473. eCollection 2023 Feb.
Cytomegalovirus (CMV) is a human herpes-type virus with variable clinical manifestations. Infections in immunocompetent patients are usually asymptomatic or mild, and severe infections are generally seen in immunosuppressed individuals. CMV colitis is not uncommon in patients with ulcerative colitis (UC) and is mostly associated with the use of steroids, immunomodulators like azathioprine, and biologics like infliximab, which have systemic immunosuppressive effects. Vedolizumab is an anti-integrin antibody that is gut-selective without any systemic effects. We report an unusual presentation of a female patient with UC who had concomitant CMV colitis and erythema nodosum, who was on vedolizumab, and not on any steroids or other immunosuppressants. She responded well to anti-viral treatment and steroids.
巨细胞病毒（CMV）是一种临床表现多样的人类疱疹病毒。免疫功能正常的患者感染通常无症状或症状轻微，而严重感染一般见于免疫抑制个体。CMV结肠炎在溃疡性结肠炎（UC）患者中并不罕见，且大多与使用具有全身免疫抑制作用的类固醇、硫唑嘌呤等免疫调节剂以及英夫利昔单抗等生物制剂有关。维多珠单抗是一种肠道选择性的抗整合素抗体，无任何全身作用。我们报告了一名患有UC的女性患者的不寻常表现，该患者同时患有CMV结肠炎和结节性红斑，正在使用维多珠单抗，未使用任何类固醇或其他免疫抑制剂。她对抗病毒治疗和类固醇反应良好。
